Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 46.00 | |
50 mg | In stock | $ 61.00 | |
100 mg | In stock | $ 97.00 | |
200 mg | In stock | $ 136.00 | |
500 mg | In stock | $ 361.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension. |
Targets&IC50 | Ca2+ channel:0.03 nM |
In vitro | In RCS rats' retinas, Nilvadipine significantly increased the expression of rhodopsin kinase and αA-crystallin, while it decreased the expression of caspase-1 and caspase-2. It also entirely inhibited arterial vasoactivity induced by Abeta in rat aortas and human brains. Furthermore, Nilvadipine (0.4 mg/kg i.v. and 2 mg/kg p.o.) was able to reduce paw edema induced by localized ischemia in mice. |
In vivo | In perfused hydronephrotic kidneys, Nilvadipine effectively dilates both afferent and efferent arterioles, enhancing renal blood flow. Moreover, in rat aortic smooth muscle cells (IC50=0.1 nM), Nilvadipine inhibits the chemotactic responses to interleukin-1, leukotriene B4, and platelet-derived growth factor. |
Synonyms | FK235, FR34235, ARC029 |
Molecular Weight | 385.37 |
Formula | C19H19N3O6 |
CAS No. | 75530-68-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 19.3 mg/mL (50 mM)
DMSO: 38.5 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Nilvadipine 75530-68-6 Membrane transporter/Ion channel Metabolism Calcium Channel FK235 FK-235 inhibit Ca channels FR34235 FR-34235 ARC029 Ca2+ channels ARC-029 FK 235 Inhibitor ARC 029 FR 34235 inhibitor