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Neohesperidin Dihydrochalcone

Catalog No. T2767 CAS 20702-77-6

Synonyms: NHDC, Neohesperidin DC, NCI-c60764

Neohesperidin Dihydrochalcone (Neohesperidin DC) is an artificial sweetener derived from citrus.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Neohesperidin Dihydrochalcone Chemical Structure

Neohesperidin Dihydrochalcone, CAS 20702-77-6

Pack Size	Availability	Price/USD
100 mg	In stock	$ 42.00
500 mg	In stock	$ 58.00
1 g	In stock	$ 74.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.8%

Purity: 99.4%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Neohesperidin Dihydrochalcone (Neohesperidin DC) is an artificial sweetener derived from citrus.
In vivo	Administration of neohesperidin dihydrochalcone significantly reduces the activities of AST and ALT, both key markers of liver damage. It also inhibits the expression of NF-κB, IL-6, IL-1β, and TNF-α proteins, which are elevated in the liver of PQ-treated mice, indicating its potential protective effects on liver inflammation and damage[3]. Furthermore, studies on Wistar Crl:(WI)WU BR rats to assess the embryotoxicity and teratogenicity of neohesperidin dihydrochalcone reveal no adverse effects at dietary levels up to 5%, the highest dose investigated. At this level, rats consumed approximately 3.3 g/kg body weight/day[4], demonstrating the compound's safety at significant dosage levels.
Cell Research	WST-8 dye is used in the cell viability assay. HIT-T15 and HUVEC cells are grown and maintained in Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine calf serum. 1000 cells in each well are incubated with various concentrations of neohesperidin dihydrochalcone (50, 100, 500 μM, 1 mM) and other compounds. After treating HIT-T15 and HUVEC cells with 500 μM HOCl, WST-8 dye is added to each well, and the absorbance is detected at 420 nm with microplate reader[1].
Source	Natural Products > Rutaceae > Citrus

Synonyms	NHDC, Neohesperidin DC, NCI-c60764
Molecular Weight	612.58
Formula	C28H36O15
CAS No.	20702-77-6

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 100 mg/mL (163.24 mM)

DMSO: 50 mg/mL (81.62 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Kroeze JH, Chem Senses, 2000, 25(5), 555-559. 2. Winnig M, et al. BMC Struct Biol, 2007, 7, 66. 3. Shi Q, et al. Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice. Int Immunopharmacol. 2015 Dec;29(2):722-9. 4. Waalkens-Berendsen DH, et al. Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats. Regul Toxicol Pharmacol. 2004 Aug;40(1):74-9.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Traditional Chinese Medicine Monomer Library Chinese Pharmacopoeia Natural Product Library Selected Plant-Sourced Compound Library Reprogramming Compound Library Flavonoid Natural Product Library Anti-Cancer Compound Library Pyroptosis Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Human Endogenous Metabolite Compound Library Plus

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Keywords

Neohesperidin Dihydrochalcone 20702-77-6 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species NHDC Neohesperidin DC Inhibitor NCI-c60764 inhibit inhibitor

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