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Nafcillin sodium monohydrate

Catalog No. T1312 CAS 7177-50-6

Synonyms: CL 8491, nafcillin sodium

Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.

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Nafcillin sodium monohydrate Chemical Structure

Nafcillin sodium monohydrate, CAS 7177-50-6

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Purity: 90.83%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.
Targets&IC50	β-lactamase:33 mM(Kd)
In vivo	Nafcillin sodium inactivates beta-lactamase by forming a covalent acyl-enzyme intermediate with Ser-70. At concentrations greater than 80 mM, and exposure times less than 200 seconds, Nafcillin completely inhibits the activity of beta-lactamase. Upon removal of Nafcillin, the inhibited enzyme can be fully reactivated with a rate constant of 2×10^-3/s at 25°C.

Synonyms	CL 8491, nafcillin sodium
Molecular Weight	454.47
Formula	C21H21N2O5SNa·H2O
CAS No.	7177-50-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 16 mg/mL (35.2 mM)

H2O: 83 mg/mL (182.6 mM)

DMSO: 84 mg/mL (184.8 mM)

References and Literature

1. Tan AK, et al. Biochem J, 1992, 281 ( Pt 1), 191-196. 2. Schwichtenberg AH. JAMA, 1965, 191:930-931.

Citations

1. Hong S, Sun Y, Sun D, et al. Microbiome assembly on Drosophila body surfaces benefits the flies to combat fungal infections. iScience. 2022: 104408

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Covalent Inhibitor Library Bioactive Compound Library FDA-Approved Drug Library Beta-Lactam Compound Library Approved Drug Library Drug-induced Liver Injury (DILI) Compound Library FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nafcillin sodium monohydrate 7177-50-6 Microbiology/Virology Antibacterial Antibiotic CL 8491 Inhibitor staphylococcal Bacterial methicillin-resistant CL8491 bactericidal inhibit methicillin-susceptible Nafcillin sodium Monohydrate nafcillin sodium CL-8491 Nafcillin sodium inhibitor

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