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Tazobactam

Catalog No. T1262 CAS 89786-04-9

Synonyms: Tazobactamum, Tazobactam acid, YTR-830H, CL-298741

Tazobactam (YTR-830H) is an antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.

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Tazobactam, CAS 89786-04-9

Pack Size	Availability	Price/USD
100 mg	In stock	$ 43.00
200 mg	In stock	$ 58.00
500 mg	In stock	$ 79.00
1 g	In stock	$ 117.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Tazobactam (YTR-830H) is an antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.

In vivo

Propylthiouracil-induced hypothyroidism reduces oxidative damage in the lung, hepatic, renal and ileal tissues probably due to hypometabolism in rats, which is associated with decreased production of reactive oxygen metabolites and enhancement of antioxidant mechanisms. [1] Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis. [2] Propylthiouracil results in lesser concentrations of thyroxine (T4) and triiodothyronine (T3), greater concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) peptides, and increase in steroidogenic gene expression after 12 hours and 48 hours in zebrafish. [3]Propylthiouracil-induced hypothyroidism is associated with increased tolerance of the isolated rat heart toischaemia-reperfusion. [4] Propylthiouracil (PTU) dramatically reduces thyroid hormones on PND21 and produced deficits in body weight that persisted to adulthood in developing rats. [5] Propylthiouracil inhibits both the synthesis of thyroid hormones in the thyroid gland and the conversion of T4 to its active form, T3. Propylthiouracil treatment significantly increases circulating TSH at both P3 and P7. Propylthiouracil exposure of adult rats, at a dose inducing modest reductions in circulating T4 concentrations and no significant effect on brain BDNF, significantly alteres the thyroid hormones and hippocampal BDNF levels in the offspring at 3 and 7 d after birth. [6]

Synonyms	Tazobactamum, Tazobactam acid, YTR-830H, CL-298741
Molecular Weight	300.29
Formula	C10H12N4O5S
CAS No.	89786-04-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (183.16 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Overington JP, et al. Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library EMA Approved Drug Library Drug Repurposing Compound Library Approved Drug Library Anti-Bacterial Compound Library Pediatric Drug Library Bioactive Compound Library Anti-Infection Compound Library Bioactive Compounds Library Max Clinical Compound Library

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Macozinone Lenampicillin hydrochloride Cloxacillin sodium monohydrate GSK2200150A Tedizolid Phosphate 5,7,3',4'-Tetramethoxyflavone WCK-5153 Sorbic acid

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tazobactam 89786-04-9 Microbiology/Virology Antibacterial Antibiotic Tazobactamum Bacterial CL298741 Tazobactam acid Inhibitor pneumonia YTR-830H CL-298741 inhibit CL 298741 inhibitor

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