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Meglutol

Catalog No. T1664 CAS 503-49-1

Synonyms: Dicrotalic acid, 3-Hydroxy-3-methylglutaric acid

Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethyl glutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate-limiting enzyme in the biosynthesis of cholesterol.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Meglutol, CAS 503-49-1

Pack Size	Availability	Price/USD
10 mg	In stock	$ 50.00
25 mg	In stock	$ 81.00
50 mg	In stock	$ 108.00
100 mg	In stock	$ 139.00

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Purity: 99.73%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Dicrotalic acid, 3-Hydroxy-3-methylglutaric acid
Molecular Weight	162.141
Formula	C6H10O5
CAS No.	503-49-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Santarelli F, et al. Ital J Pediatr. 2013 May 24;39:33.

Related compound libraries

This product is contained In the following compound libraries：

Autophagy Compound Library Human Metabolite Library Anti-Cancer Metabolism Compound Library Metabolism Compound Library Lipid Metabolism Compound Library Bioactive Compounds Library Max Anti-Cardiovascular Disease Compound Library Natural Product Library for HTS Natural Product Library Inhibitor Library

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Hesperetin 7-O-glucoside Apomine Rosuvastatin calcium Fluvastatin sodium Atorvastatin lactone Tert-Buthyl Pitavastatin Monacolin J HMG499

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Meglutol 503-49-1 Autophagy Metabolism HMG-CoA Reductase Endogenous Metabolite inhibit Dicrotalic acid Inhibitor 3-Hydroxy-3-methylglutaric acid HMG-CoA Reductase (HMGCR) inhibitor

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