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Licochalcone E

Catalog No. TN1055 CAS 864232-34-8

Licochalcone E is a potential LXRβ agonist.

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Licochalcone E, CAS 864232-34-8

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1 mg	In stock	$ 200.00
5 mg	In stock	$ 415.00

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Purity: 98.09%

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Description	Licochalcone E is a potential LXRβ agonist.
In vitro	In this study, the quantitative pharmacophores were constructed by 3D-QSAR pharmacophore (Hypogen) method based on the LXRβ agonists. The optimal pharmacophore model containing one hydrogen bond acceptor, two hydrophobics and one ring aromatic was obtained based on five assessment indictors, including the correlation between predicted value and experimental value of the compounds in training set (correlation), α?cost of the models (α?cost), hit rate of active compounds (HRA), identification of effectiveness index (IEI) and comprehensive evaluation index (CAI). And the values of the five assessment indicators were 0.95, 128.65, 84.44%, 2.58 and 2.18 respectively. The best model as a query to screen the traditional Chinese medicine database (TCMD), a list of 309 compounds was obtained andwere then refined using Libdock program. Finally, based on the screening rules of the Libdock score of initial compound and the key interactions between initial compound and receptor, four compounds, demethoxycurcumin, isolicoflavonol, Licochalcone E and silydianin, were selected as potential LXRβ agonists[1]
Source	Natural Products > Fabaceae > Glycyrrhiza

Molecular Weight	338.4
Formula	C21H22O4
CAS No.	864232-34-8

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store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Discovery of potential LXRβ agonists from Chinese herbs using molecular simulation methods.Zhongguo Zhong Yao Za Zhi. 2016 Aug;41(16):3065-3071.

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Keywords

Licochalcone E 864232-34-8 Apoptosis DNA Damage/DNA Repair Metabolism TNF Liver X Receptor PPAR inhibitor inhibit

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