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LY392098

Catalog No. T27951   CAS 211311-39-6
Synonyms: LY-392098, LY 392098, AMPA receptor modulator-3

LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.

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LY392098 Chemical Structure
LY392098, CAS 211311-39-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 98.00
2 mg In stock $ 145.00
5 mg In stock $ 247.00
10 mg In stock $ 397.00
25 mg In stock $ 663.00
50 mg In stock $ 945.00
100 mg In stock $ 1,280.00
500 mg In stock $ 2,570.00
1 mL * 10 mM (in DMSO) In stock $ 259.00
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Purity: 99.85%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.
In vitro LY392098 potentiates responses mediated by 100 μM L-glutamate in HEK-293 cells expressing iGluR4 flip[3].
Synonyms LY-392098, LY 392098, AMPA receptor modulator-3
Molecular Weight 335.44
Formula C18H22FNO2S
CAS No. 211311-39-6

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225mg/mL (670.8mM), sonification is recommended.

TargetMolReferences and Literature

1. O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. Review. 2. Farley S, et al. Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm. Int J Neuropsychopharmacol. 2010 Oct;13(9):1207-18. 3. Kasper Harpsøe, et al. Prediction of the binding mode of biarylpropylsulfonamide allosteric AMPA receptor modulators based on docking, GRID molecular interaction fields and 3D-QSAR analysis. J Mol Graph Model. 2008 Jan;26(5):874-83.

Related compound libraries

This product is contained In the following compound libraries:
Neuronal Signaling Compound Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library

Related Products

Related compounds with same targets
L-Glutamic acid AMPA receptor modulator-4 ZL006 Rislenemdaz Memantine hydrochloride DQP-26 Ifenprodil Tartrate Transcrocetin

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Keywords

LY392098 211311-39-6 Membrane transporter/Ion channel Neuroscience GluR iGluR LY-392098 LY 392098 AMPA receptor modulator-3 inhibitor inhibit

 

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