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Isoalantolactone

Catalog No. T2829 CAS 470-17-7

Synonyms: Isohelenin, (+)-Isoalantolactone

Isoalantolactone, isolated from Inula spp., can inhibit the growth of several types of Y cells.

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Isoalantolactone, CAS 470-17-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Isoalantolactone, isolated from Inula spp., can inhibit the growth of several types of Y cells.

Synonyms	Isohelenin, (+)-Isoalantolactone
Molecular Weight	232.31
Formula	C15H20O2
CAS No.	470-17-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 60 mg/mL (258.26 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Di W, et al. Oncol Rep. 2014 Oct;32(4):1585-93. 2. Ding, Yun-he, Yun-duan Song, Ya-xian Wu, Hui-qiong He, Tian-hong Yu, Yu-dong Hu, De-peng Zhang et al. Isoalantolactone suppresses LPS-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury [J]. Acta pharmacologica Sinica. 2019 Jan;40(1):64-74.

Citations

1. Ding Y, Song Y, Wu Y, et al. Isoalantolactone suppresses LPS-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury. Acta Pharmacologica Sinica. 2019, 40(1): 64-74

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Isoalantolactone 470-17-7 Apoptosis Autophagy Metabolism Microbiology/Virology Endogenous Metabolite Antibacterial Inhibitor Isohelenin inhibit (+)-Isoalantolactone Bacterial inhibitor

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