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Germacrone

Catalog No. T2945 CAS 6902-91-6

Germacrone, a major active component found in Curcuma zedoaria oil product, shows anti-inflammatory, antiandrogenic, and antivirus activities. It also inhibits the proliferation of glioma cells by promoting apoptosis.

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Germacrone, CAS 6902-91-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
10 mg	In stock	$ 74.00
25 mg	In stock	$ 126.00
50 mg	In stock	$ 162.00
100 mg	In stock	$ 210.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 99.87%

Purity: 99.86%

Purity: 98.88%

Purity: 98.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Germacrone, a major active component found in Curcuma zedoaria oil product, shows anti-inflammatory, antiandrogenic, and antivirus activities. It also inhibits the proliferation of glioma cells by promoting apoptosis.
In vitro	Germacrone can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. Germacrone might be a new potent chemopreventive drug candidate for liver cancer via regulating the expression of proteins related to G2/M cell cycle and apoptosis, and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone. Germacrone moderately inhibits CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 uM, and produces two oxidized metabolites and four glutathione conjugates.
In vivo	Germacrone shows antiviral activity against the H1N1 and H3N2 influenza A viruses and the influenza B virus in a dose-dependent manner, exerts an effective protection of mice from lethal infection and reduces the virus titres in the lung.

Molecular Weight	218.33
Formula	C15H22O
CAS No.	6902-91-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.18 mg/mL (10 mM), Sonification is recommended

References and Literature

1. Xie XH, et al. Germacrone reverses Adriamycin resistance through cell apoptosis in multidrug-resistant breast cancer cells. Exp Ther Med. 2014 Nov;8(5):1611-1615. 2. Pimkaew P, et al. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. Toxicol In Vitro. 2013 Sep;27(6):2005-12. 3. An JF, et al. The effects of germacrone on lipopolysaccharide-induced acute lung injury in neonatal rats. Cell Mol Biol (Noisy-le-grand). 2014 Nov 16;60(4):8-12.

Citations

1. Li Z, Wang Z, Dong F, et al. Germacrone Attenuates Hepatic Stellate Cells Activation and Liver Fibrosis via Regulating Multiple Signaling Pathways. Frontiers in Pharmacology. 2021: 2750. 2. Schepetkin, Igor A., et al. Chemical Composition and Immunomodulatory Activity of Essential Oils from Rhododendron albiflorum. Molecules. 26.12 (2021): 3652. 3. Kaduk J A, Gates-Rector S, Blanton T N. Crystal structure of a second polymorph of germacrone, C15H22O. Powder Diffraction. 2022: 1-7. 4. Wang Y, He X, Xue M, et al.Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy.Free Radical Research.2023 (just-accepted): 1-36.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Miao medicine Compound Library Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Food as Medicine Compound Library Terpene Natural Product Library Bioactive Compounds Library Max Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Germacrone 6902-91-6 Immunology/Inflammation Metabolism Microbiology/Virology P450 Antiviral Influenza Virus inhibit Inhibitor inhibitor

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