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Fisetin

Catalog No. T2879 CAS 528-48-3

Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidant, anticancer, neuroprotection effects.

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Fisetin, CAS 528-48-3

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 41.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 98.31%

Purity: 97.22%

Purity: 94.14%

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Storage & Solubility Information

Description	Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidant, anticancer, neuroprotection effects.
In vitro	Fisetin (3,7,3',4'-tetrahydroxyflavone) is a naturally found flavonol in many fruits and vegetables and is known to have anti-aging, anti-cancer and anti-viral effects. Fisetin inhibits lipid accumulation and suppresses the expression of PPARγ in 3T3-L1 cells. Fisetin suppressed early stages of preadipocyte differentiation, and induced expression of Sirt1. Depletion of Sirt1 abolished the inhibitory effects of fisetin on intracellular lipid accumulation and on PPARγ expression. Mechanistically, fisetin facilitated Sirt1-mediated deacetylation of PPARγ and FoxO1, and enhanced the association of Sirt1 with the PPARγ promoter, leading to suppression of PPARγ transcriptional activity, thereby repressing adipogenesis. Lowering Sirt1 levels reversed the effects of fisetin on deacetylation of PPARγ and increased PPARγ transactivation[1].
In vivo	Pretreatment with fisetin significantly alleviated the elevated levels of serum creatinine and blood urea nitrogen in LPS-treated mice. Consistently, LPS induced renal damage as implied by histopathological score and the increased injury markers NGAL and KIM-1, which was attenuated by fisetin. Meanwhile, LPS injection triggered proinflammatory cytokine production and inflammation related proteins in the kidneys. However, fisetin inhibited renal expression of IL-6, IL-1β, TNF-α, HMGB1, iNOS and COX-2 to improve inflammatory response. Furthermore, fisetin effectively reduced the number of TUNEL positive apoptotic cells and suppressed apoptotic protein of Bcl-2, BAX and cleaved caspase-3 in the kidneys of LPS-induced septic AKI[2].
Source	Natural Products > Anacardiaceae > Toxicodendron

Molecular Weight	286.24
Formula	C15H10O6
CAS No.	528-48-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28.6 mg/mL (100 mM)

Ethanol: 2.9 mg/mL (10 mM)

References and Literature

1. Kim SC, et al. Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun. 2015 Nov 27;467(4):638-44. 2. Ren Q , F Guo, Tao S , et al. Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice[J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, 122:109772. 3. Kim SC, et al. Biochem Biophys Res Commun. 2015 Nov 27;467(4):638-44. 4. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin[J]. Biochemical and Biophysical Research Communications. 2020 5. Zhang H, Zhang H, Wu X, et al. Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling[J]. Acta Pharmacologica Sinica. 2020, 41(10): 1348-1356.

Citations

1. Zhang H, Zhang H, Wu X, et al. Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling. Acta Pharmacologica Sinica. 2020, 41(10): 1348-1356. 2. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin. Biochemical and Biophysical Research Communications. 2020

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Miao medicine Compound Library Chromatin Modification Compound Library Anti-Breast Cancer Compound Library Anti-Tumor Natural Product Library Immunology/Inflammation Compound Library Oxidation-Reduction Compound Library

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Keywords

Fisetin 528-48-3 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism TNF Sirtuin PPAR inhibit TNF Receptor Tumor Necrosis Factor Receptor TNFR Inhibitor Peroxisome proliferator-activated receptors inhibitor

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