Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EUK-134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 30.00 | |
10 mg | In stock | $ 47.00 | |
25 mg | In stock | $ 89.00 | |
50 mg | In stock | $ 162.00 | |
100 mg | In stock | $ 270.00 | |
200 mg | In stock | $ 418.00 | |
500 mg | In stock | $ 678.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 40.00 |
Description | EUK-134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril. |
In vitro | EUK 134 shows potent catalase and SOD activities, and protects human fibroblasts against cytotoxicity by glucose and glucose oxidase. [1] EUK 134 (20 μM) prevents Aβ-induced microglial proliferation in vitro. [2] In SK-N-MC cells, EUK134 protects neuronal cells against H(2)O(2) toxicity by attenuating oxidative stress through inhibition of MAPK pathway, and also results in decreased expression of pro-apoptotic genes p53 and Bax as well as enhanced expression of anti-apoptotic Bcl-2 gene. [3] EUK 134 significantly inhibits amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein). [4] |
In vivo | EUK 134 (2.5 mg/kg), in a middle cerebral artery occlusion model, significantly reduces brain infarct size, and apparently prevents further infarct growth. [1] EUK-134 prevents oxidative stress and attenuates rat brain damage induced by systemic administration of systemic kainic acid (KA). [5] |
Synonyms | EUK 134 |
Molecular Weight | 416.74 |
Formula | C18H18ClMnN2O4 |
CAS No. | 81065-76-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 77 mg/mL (184.8 mM)
H2O: 11 mg/mL (26.4 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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EUK-134 81065-76-1 Neuroscience Beta Amyloid Inhibitor Free mitoprotective Nephrotoxicity antioxidant SODm species EUK 134 Nuclear factor-kappaB NRK-52E radicals NF-κB inhibit oxygen Nuclear factor-κB catalase Reactive EUK134 Superoxide mimetic SOD dismutase inhibitor