Powder: -20°C for 3 years | In solvent: -80°C for 1 year
E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 47.00 | |
2 mg | In stock | $ 67.00 | |
5 mg | In stock | $ 105.00 | |
10 mg | In stock | $ 178.00 | |
25 mg | In stock | $ 372.00 | |
50 mg | In stock | $ 549.00 | |
100 mg | In stock | $ 783.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 116.00 |
Description | E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. |
In vitro | Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. [1]E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease. [4] |
In vivo | In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. [2] E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. [3] |
Synonyms | NSC 694279, EP 475, Loxistatin Acid |
Molecular Weight | 314.38 |
Formula | C15H26N2O5 |
CAS No. | 76684-89-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 2 mg/mL (6.36 mM)
DMSO: 58 mg/mL (184.5 mM)
Ethanol: 58 mg/mL (184.5 mM)
You can also refer to dose conversion for different animals. More
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E 64c 76684-89-4 Microbiology/Virology Proteases/Proteasome Cysteine Protease SARS-CoV EP-475 Cathepsin NSC694279 NSC 694279 EP 475 NSC-694279 Loxistatin Acid inhibit SARS coronavirus Inhibitor EP475 inhibitor