Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
Description | Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. |
In vitro | Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. [1]E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease. [4] |
In vivo | In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. [2] E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. [3] |
Synonyms | Loxistatin Acid, NSC 694279, EP 475 |
Molecular Weight | 314.38 |
Formula | C15H26N2O5 |
CAS No. | 76684-89-4 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 58 mg/mL (184.5 mM)
Ethanol: 58 mg/mL (184.5 mM)
H2O: 2 mg/mL (6.36 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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