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E 64c

Catalog No. T6573   CAS 76684-89-4
Synonyms: Loxistatin Acid, NSC 694279, EP 475

Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.

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E 64c, CAS 76684-89-4
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Purity 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
In vitro Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. [1]E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease. [4]
In vivo In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. [2] E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. [3]
Synonyms Loxistatin Acid, NSC 694279, EP 475
Molecular Weight 314.38
Formula C15H26N2O5
CAS No. 76684-89-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 58 mg/mL (184.5 mM)

Ethanol: 58 mg/mL (184.5 mM)

H2O: 2 mg/mL (6.36 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. McGowan EB, et al. Biochem Biophys Res Commun. 1989, 158(2), 432-435. 2. Noda T, et al. J Biochem. 1981, 90(3), 893-896. 3. Inuzuka T, et al. Brain Res. 1990, 526(1), 177-179. 4. Hook VY, et al. J Neurosci Res. 2003, 74(3), 393-405.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Inhibitor Library Covalent Inhibitor Library Protease Inhibitor Library Target-Focused Phenotypic Screening Library Anti-Aging Compound Library Anti-Infection Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets
FOY 251 Remdesivir Aloxistatin GS-621763 4'-O-Methylbavachalcone Nafamostat mesylate Auranofin PLpro inhibitor

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