Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dilazep dihydrochloride is an adenosine uptake inhibitor. Dilazep dihydrochloride also inhibits the ischemic damage, membrane transport of nucleosides and platelet aggregation. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 213.00 | |
100 mg | In stock | $ 347.00 | |
200 mg | In stock | $ 498.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 59.00 |
Description | Dilazep dihydrochloride is an adenosine uptake inhibitor. Dilazep dihydrochloride also inhibits the ischemic damage, membrane transport of nucleosides and platelet aggregation. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine. |
In vitro | Dilazep, NBI and Dipyridamole have been reported to inhibit the uptake of adenosine into different cells. The uptake mechanism has been studied extensively in vitro. In these compounds, Dilazep and NBI are almost 10 times more effective than Dipyridamole. Only Dilazep is water soluble and no solubility aiding organic solvent is needed for preparing an aqueous solution[1]. |
In vivo | Dilazep acts by inhibiting phospholipase activation in reperfused heart mitochondria and preventing lipid peroxidation in cerebral ischemia and reperfusion, potentially reducing ischemic cerebral injury through increased cerebral blood flow and protection of vascular endothelial cell membranes. Importantly, low doses (0.04-0.1 mg/kg/min) amplify the effects of adenosine, significantly enhancing superior mesenteric arterial conductance (SMAC) and raising arterial plasma adenosine levels, with a clear correlation observed between adenosine levels and SMAC changes, showing a 193.4% change in SMAC and an EC50 value of 2.8 μM. However, the vasodilatory potentiation by Dilazep is nullified by 8-phenyltheophylline, though this does not interfere with isoproterenol-induced relaxation. |
Molecular Weight | 677.61 |
Formula | C31H46Cl2N2O10 |
CAS No. | 20153-98-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (88.55 mM), Sonication is recommended.
H2O: 80 mg/mL (118.06 mM)
You can also refer to dose conversion for different animals. More
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Dilazep dihydrochloride 20153-98-4 Others ischemic Adenosine Dilazep Dihydrochloride Dilazep uptake vasodilation potentiate Inhibitor cerebral damage inhibit inhibitor