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Dexmedetomidine hydrochloride

Catalog No. T6466 CAS 145108-58-3

Synonyms: Precedex, (+)-Medetomidine hydrochloride, (S)-Medetomidine hydrochloride, Dexmedetomidine HCl

Dexmedetomidine hydrochloride (Precedex) is an imidazole derivative that is an agonist of the adrenergic alpha-2 receptor. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Dexmedetomidine hydrochloride Chemical Structure

Dexmedetomidine hydrochloride, CAS 145108-58-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 35.00
10 mg	In stock	$ 50.00
25 mg	In stock	$ 90.00
50 mg	In stock	$ 162.00
100 mg	In stock	$ 238.00
200 mg	In stock	$ 358.00
500 mg	In stock	$ 593.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 100.00%

Purity: 99.86%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dexmedetomidine hydrochloride (Precedex) is an imidazole derivative that is an agonist of the adrenergic alpha-2 receptor. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound.
Targets&IC50	α2-adrenoceptor:1.08 nM (IC50)
In vivo	Conivaptan (0.03, 0.1 and 0.3 mg/kg i.v.) dose-dependently increases urine volume and reduces urine osmolality in both myocardial infarction and sham-operated rats. Conivaptan (0.3 mg/kg i.v.) significantly reduces right ventricular systolic pressure, left ventricular end-diastolic pressure, lung/body weight and right atrial pressure in myocardial infarction rats. Conivaptan (0.3 mg/kg i.v.) significantly increases dP/dt(max)/left ventricular pressure in myocardial infarction rats. [1] Conivaptan produces an acute increase in urine volume (UV), a reduction in osmolality (UOsm) and, at the end of the investigation, cirrhotic rats receiving the V(1a)/V(2)-AVP receptor antagonist does not show hyponatremia or hypoosmolality. Conivaptan also normalizes U(Na)V without affecting creatinine clearance and arterial pressure. [2] Conivaptan (0.01 to 0.1 mg/kg i.v.) exerts a dose-dependent diuretic effect in dogs without an increase in the urinary excretion of electrolytes, inhibits the pressor effect of exogenous vasopressin in a dose-dependent manner (0.003 to 0.1 mg/kg i.v.) and, at the highest dose (0.1 mg/kg i.v.), almost completely blocks vasoconstriction caused by exogenous vasopressin. Conivaptan (0.1 mg/kg i.v.) improves cardiac function, as evidenced by significant increases in left ventricular dP/dtmax, cardiac output and stroke volume, and reduces preload and afterload, as evidenced by significant decreases in left ventricular end-diastolic pressure and total peripheral vascular resistance in dogs with congestive heart failure. [3]
Kinase Assay	In vitro HDAC assay:HDAC activity is analyzed by using an HDAC assay kit. This assay is based on the ability of DU-145 nuclear extract, which is rich in HDAC activity, to mediate the deacetylation of the biotinylated [3H]-acetyl histone H4 peptide that is bound to streptavidin agarose beads. The release of [3H]-acetate into the supernatant is measured to calculate the HDAC activity. Sodium butyrate (0.25-1 mM) is used as a positive control.

Synonyms	Precedex, (+)-Medetomidine hydrochloride, (S)-Medetomidine hydrochloride, Dexmedetomidine HCl
Molecular Weight	236.74
Formula	C13H16N2·HCl
CAS No.	145108-58-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 23.7 mg/mL (100 mM)

H2O: 23.7 mg/mL (100 mM)

References and Literature

1. Xue F, Zhang W, Chu HC.Kidney Int. 2016 May;89(5):1164. 2. Xue FS, Li RP, Liu GP, Sun C.Kidney Int. 2016 May;89(5):1163-4.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library EMA Approved Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library GPCR Compound Library Anti-Cancer Approved Drug Library Membrane Protein-targeted Compound Library Anti-Cancer Clinical Compound Library CNS-Penetrant Compound Library

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Tamsulosin Rafabegron Tetrahydrozoline hydrochloride Tetrahydroalstonine Nicardipine hydrochloride Salbutamol (S)-Terazosin Naftopidil

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dexmedetomidine hydrochloride 145108-58-3 GPCR/G Protein Neuroscience Adrenergic Receptor Precedex inhibit Inhibitor adrenoceptor (+)-Medetomidine (+)-Medetomidine hydrochloride Dexmedetomidine analgesia (S)-Medetomidine hydrochloride sedation Beta Receptor anxiolysis (S)-Medetomidine Dexmedetomidine Hydrochloride Dexmedetomidine HCl Medetomidine Hydrochloride inhibitor

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