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DIDS sodium salt

Catalog No. T18975 CAS 67483-13-0

Synonyms: MDL101114ZA, 4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠[蛋白质改性试剂]

DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.

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DIDS sodium salt, CAS 67483-13-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DIDS sodium salt is a dual inhibitor of ABCA1 and VDAC1.
In vitro	DIDS (<400 μM) has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation [2].

Synonyms	MDL101114ZA, 4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠[蛋白质改性试剂]
Molecular Weight	500.48
Formula	C16H10N2Na2O6S4
CAS No.	67483-13-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (100.30 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Tsou CY, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf). 2014 Apr;210(4):799-810. 2. Chen H, et al. Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages. Apoptosis. 2014 Dec;19(12):1712-26.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Ion Channel Inhibitor Library Bioactive Compound Library

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Related compounds with same targets

Tepotinib hydrochloride(1 : x) CCTA-1523 Erythrodiol Acridone DIDS sodium salt Thiethylperazine dimaleate MMAF sodium Glipizide

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DIDS sodium salt 67483-13-0 离子通道 ABC VDAC MDL101114ZA inhibit Inhibitor Voltage-dependent anion channel DIDS inhibitor

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