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DIDS sodium salt

Name: DIDS sodium salt
Brand: TargetMol
SKU: T18975
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18975Cas No. 67483-13-0

Alias MDL101114ZA

DIDS sodium salt (MDL101114ZA) is a dual inhibitor of the proteins ABCA1 and VDAC1.

DIDS sodium salt

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Purity: 99.34%

Catalog No. T18975Alias MDL101114ZACas No. 67483-13-0

DIDS sodium salt (MDL101114ZA) is a dual inhibitor of the proteins ABCA1 and VDAC1.

Pack Size	Price	Availability
10 mg	$33	In Stock
25 mg	$51	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.34%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	DIDS sodium salt (MDL101114ZA) is a dual inhibitor of the proteins ABCA1 and VDAC1.
Targets&IC50	Cl⁻ uptake (neuroblastoma cells):150 nM, RAD51:2 μM (KD), ClC-Ka chloride channel:100 μM
In vitro	DIDS (<400 μM) has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation [2].
Cell Research	Instructions a. Solution preparation: Dissolve DIDS sodium salt (MDL101114ZA) in DMSO to prepare a 100 mmol/L storage solution, store it in aliquots at -20℃ or -80℃, and store it at 4℃ for future use. b. Operation steps: Dilute the storage solution to 100 µmol/L before use and add it to the cells for incubation.
Synonyms	MDL101114ZA

Chemical Properties

Molecular Weight	498.5
Formula	C₁₆H₈N₂Na₂O₆S₄
Cas No.	67483-13-0
Smiles	O.[Na+].[Na+].[O-]S(=O)(=O)c1cc(ccc1C=Cc1ccc(cc1S([O-])(=O)=O)N=C=S)N=C=S
Relative Density.	1.54g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125.3 mg/mL (251.35 mM), Sonication and heating are recommended.

H2O: 9.09 mg/mL (18.23 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0060 mL	10.0301 mL	20.0602 mL	100.3009 mL
5 mM	0.4012 mL	2.0060 mL	4.0120 mL	20.0602 mL
10 mM	0.2006 mL	1.0030 mL	2.0060 mL	10.0301 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1003 mL	0.5015 mL	1.0030 mL	5.0150 mL
50 mM	0.0401 mL	0.2006 mL	0.4012 mL	2.0060 mL
100 mM	0.0201 mL	0.1003 mL	0.2006 mL	1.0030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc