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D159687

Catalog No. T5474 CAS 1155877-97-6

Synonyms: D 159687

D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit.

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D159687, CAS 1155877-97-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 77.00
25 mg	In stock	$ 163.00
50 mg	In stock	$ 263.00
100 mg	In stock	$ 423.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 95.02%

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Description	D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit.
In vitro	D159687 induced a transient increase in CREB phosphorylation which peaked at 6 hrs after treatment ( F (3, 20) = 3.731, P = 0.0425). CREB phosphorylation was optimal at 1 μM ( F (3, 20) = 4.194, P = 0.0302).
Cell Research	cAMP concentrations were measured using the enzyme-linked immunosorbent assay.?On the day of treatment, the attached HT-22 cells were washed with warm phosphate buffer saline and then incubated for 10 min with PBS supplemented with various concentrations of D159687 and further for 10 min with 10 nM isoproterenol in the system52.?After incubation, PBS containing the drugs was removed and the plates were let dry roughly before 200 μl HCl (0.1 M) was added to each well to lyse the cells.?Cell lysates were collected into Eppendorf tubes and centrifuged at 800 g for 15 min. Supernatants were collected for immediate assay or stored frozen for assay later using the cAMP complete ELISA kit according to the assay protocol.

Synonyms	D 159687
Molecular Weight	366.84
Formula	C21H19ClN2O2
CAS No.	1155877-97-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (408.90 mM)

References and Literature

1. Zhang C, et al. Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Sci Rep. 2017 Jan 5;7:40115.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Anti-Metabolism Disease Compound Library Metabolism Compound Library Anti-Alzheimer's Disease Compound Library Bioactive Compound Library NO PAINS Compound Library Anti-Cardiovascular Disease Compound Library

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Keywords

D159687 1155877-97-6 Metabolism PDE Inhibitor inhibit D-159687 D 159687 Phosphodiesterase (PDE) inhibitor

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