pde — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10201	PDE IV-IN-1		PDE
	PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease and other inflammatory diseases, and is a potential compound...		PDE
T68191	PDE-I2
	PDE-I2 is a parasite schizogony inhibitor.
T12389	PDE-9 inhibitor		Others
	PDE-9 inhibitor is used for treatment neurodegenerative diseases.		Others
T21965	MBCQ		PDE
	MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.		PDE
T6462	Deltarasin		PDE , Ras
	Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.		PDE , Ras
T5411	PDE10-IN-1	SEP-0372814	PDE
	PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.		PDE
T6054	GSK256066		PDE
	GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.		PDE
T2129	Zaprinast		PDE
	Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist. It has a strong activating effect on rat GPR35 and a certain activating effect on human GPR35. It reduces vascular remodeling through a...		PDE
T12395	PDE9-IN-1		PDE
	PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).		PDE
T10676	Carbodenafil		PDE
	Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).		PDE
TN1266	3-O-Methylquercetin		IL Receptor , cAMP , PDE
	3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentr...		IL Receptor , cAMP , PDE
T4695	CP671305		PDE
	CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.		PDE
T3631	PF-8380		PDE
	PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhib...		PDE
T7888	Enpp-1-IN-1		PDE
	Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)		PDE
T4462	Roflumilast N-oxide		PDE
	Roflumilast N-oxide is an inhibitor of PDE type 4.		PDE
T10410	ATX inhibitor 1		PDE
	ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).		PDE
T8787	Drotaverine hydrochloride		PDE
	Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor，and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela...		PDE
T1618	Dipyridamole	Persantin,Dypyridamole,Dipyridamol,NSC-515776,Dipyudamine	PDE
	Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.		PDE
T13448	(R)-(-)-Rolipram	(R)-Rolipram,(-)-Rolipram	DNA-PK , Others
	(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.		DNA-PK , Others
T1681	Aminophylline	Phyllocontin	PDE , Adenosine Receptor
	Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.		PDE , Adenosine Receptor