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Bozitinib

Catalog No. T10585   CAS 1440964-89-5
Synonyms: CBT-101, PLB-1001

Bozitinib (PLB-1001) (PLB-1001) is a highly selective inhibitor of the c-MET kinase with blood-brain barrier permeability. Bozitinib binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily.

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Bozitinib Chemical Structure
Bozitinib, CAS 1440964-89-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 135.00
5 mg In stock $ 289.00
10 mg In stock $ 455.00
25 mg In stock $ 753.00
50 mg In stock $ 1,060.00
100 mg In stock $ 1,430.00
1 mL * 10 mM (in DMSO) In stock $ 317.00
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Purity: 99.48%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Bozitinib (PLB-1001) (PLB-1001) is a highly selective inhibitor of the c-MET kinase with blood-brain barrier permeability. Bozitinib binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily.
In vitro Bozitinib (30 μM; 6 hours) inhibits the phosphorylation of MET and STAT3. Bozitinib has a robust inhibitory effect on MET and its downstream signaling pathways.
Synonyms CBT-101, PLB-1001
Molecular Weight 424.38
Formula C20H15F3N8
CAS No. 1440964-89-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 47 mg/mL (110.74 mM), sonification is recommended.

TargetMolReferences and Literature

1. Hu H, et al. Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor. Cell. 2018 Nov 29;175(6):1665-1678.e18.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Highly Selective Inhibitor Library Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Bioactive Compound Library Anti-Liver Cancer Compound Library Inhibitor Library Anti-Colorectal Cancer Compound Library

Related Products

Related compounds with same targets
X-376 C-Met inhibitor D9 SGI-7079 SAR125884 hydrochlorid (1116743-46-4(free base)) BMS 777607 PF-04217903 phenolsulfonate c-Kit-IN-1 Herbacetin

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Keywords

Bozitinib 1440964-89-5 Tyrosine Kinase/Adaptors c-Met/HGFR CBT-101 PLB1001 Vebreltinib CBT 101 inhibit PLB-1001 CBT101 PLB 1001 Inhibitor inhibitor

 

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