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Avobenzone

Name: Avobenzone
Brand: TargetMol
SKU: T0695
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0695Cas No. 70356-09-1

Alias Butyl methoxydibenzoylmethane, BF2AVB

Avobenzone is a dibenzoylmethane endocrine disruptor that binds directly to estrogen receptor β, acting as an estrogen agonist. It is one of the most widely used filters in sunscreens for photoprotection of skin in the UV band.

Avobenzone

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Purity: 97.93%

Catalog No. T0695Alias Butyl methoxydibenzoylmethane, BF2AVBCas No. 70356-09-1

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$48	In Stock	In Stock
500 mg	$68	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Avobenzone AI Summary

Avobenzone exhibits a wide range of bioactivities across various biological targets and assays. It demonstrates potent inhibitory effects on Lamin A Splicing, RecQ-Like DNA Helicase 1, HSD17B4, APE1, Tyrosyl-DNA Phosphodiesterase, Aldehyde Dehydrogenase 1, 15-hLO, ERK Signaling Pathway, JMJD2A-Tudor Domain, GCN5L2, T. brucei phosphofructokinase, Polymerase Kappa, malarial parasite plastid, USP1/UAF1, Glutaminase, Hepatitis C Virus, human tyrosyl-DNA phosphodiesterase 1, Plasmodium falciparum proliferation, PTHR, cellular entry of Lassa Virus, AMA1-RON, and Ebola Virus entry and blockage, with potency levels ranging from nanomolar to micromolar concentrations. In assays with OATP1B1 and OATP1B3-transfected CHO cells, the compound inhibits sodium fluorescein uptake by 123.97% and 103.0% respectively at 10 μM, indicating significant bioactivity in these cell lines. It also possesses in vitro photoprotection properties, with a UVA protection factor (UVAPF) of 39.0 and a UVA to UVB ratio of 1.8, demonstrating balanced protective capabilities against UVA and UVB radiation. Moreover, Avobenzone reduces cell viability in Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.8383, and exhibits antiviral activity by inhibiting virus-induced cytotoxicity in VERO-6 cells with an IC50 value greater than 20000 nM after 48 hours at 10 μM concentration. This suggests its potential effectiveness in mitigating viral activity within infected cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Avobenzone is a dibenzoylmethane endocrine disruptor that binds directly to estrogen receptor β, acting as an estrogen agonist. It is one of the most widely used filters in sunscreens for photoprotection of skin in the UV band.
Synonyms	Butyl methoxydibenzoylmethane, BF2AVB

Chemical Properties

Molecular Weight	310.39
Formula	C₂₀H₂₂O₃
Cas No.	70356-09-1
Smiles	C(CC(=O)C1=CC=C(OC)C=C1)(=O)C2=CC=C(C(C)(C)C)C=C2
Relative Density.	1.221. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 9 mg/mL (29 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 75 mg/mL (241.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (10.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2218 mL	16.1088 mL	32.2175 mL	161.0877 mL
5 mM	0.6444 mL	3.2218 mL	6.4435 mL	32.2175 mL
10 mM	0.3222 mL	1.6109 mL	3.2218 mL	16.1088 mL
20 mM	0.1611 mL	0.8054 mL	1.6109 mL	8.0544 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0644 mL	0.3222 mL	0.6444 mL	3.2218 mL
100 mM	0.0322 mL	0.1611 mL	0.3222 mL	1.6109 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc