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Avitinib

Catalog No. T3024   CAS 1557267-42-1
Synonyms: AC0010

Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of Ys, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Avitinib Chemical Structure
Avitinib, CAS 1557267-42-1
Pack Size Availability Price/USD Quantity
2 mg In stock $ 41.00
5 mg In stock $ 67.00
10 mg In stock $ 117.00
25 mg In stock $ 228.00
50 mg In stock $ 372.00
100 mg In stock $ 549.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 99.87%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of Ys, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.
Targets&IC50 EGFR (L858R/T790M):0.18 nM, BTK:0.4 nM, JAK3:0.09 nM
Synonyms AC0010
Molecular Weight 487.53
Formula C26H26FN7O2
CAS No. 1557267-42-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 88 mg/mL(180.5 mM)

TargetMolReferences and Literature

1. Xu X, et al. Mol Y Ther. 2016 Nov;15(11):2586-2597.

Related compound libraries

This product is contained In the following compound libraries：
Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Highly Selective Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Inhibitor Library Immunology/Inflammation Compound Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets
Icotinib WZ4002 Boehmenan Methyl 2,5-dihydroxycinnamate Simotinib Naquotinib mesylate WS6 Rociletinib

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Avitinib 1557267-42-1 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells Tyrosine Kinase/Adaptors BTK JAK EGFR Epidermal growth factor receptor Bruton tyrosine kinase AC-0010 AC 0010 HER1 Inhibitor AC0010 Btk Abivertinib inhibit ErbB-1 inhibitor

 

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