Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM). Atpenin A5 is also an effective mKATP channel agonist and cardioprotective agent[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 255.00 | |
2 mg | In stock | $ 346.00 | |
5 mg | In stock | $ 522.00 | |
10 mg | In stock | $ 759.00 | |
25 mg | In stock | $ 1,170.00 | |
50 mg | In stock | $ 1,580.00 |
Description | Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM). Atpenin A5 is also an effective mKATP channel agonist and cardioprotective agent[1]. |
In vitro | Atpenin A5 effectively inhibits submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, exhibiting IC50 values of 8.3 nM, 9.3 nM, and 8.5 nM, respectively. It acts as a potent, specific inhibitor of complex II. Moreover, at a concentration of 1 nM, Atpenin A5 (AA5) activates the mitochondrial ATP-sensitive potassium (mKATP) channel and offers protection against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes[1]. |
In vivo | Atpenin A5 is a potent inhibitor of succinate dehydrogenase (SDH). SDH inhibition by Atpenin A5 promotes cardiomyocyte mitosis and regeneration in the postnatal heart after myocardial infarction (MI). Atpenin A5-injected (100 μg/kg) mice demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls[2]. |
Molecular Weight | 366.24 |
Formula | C15H21Cl2NO5 |
CAS No. | 119509-24-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (273.04 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Atpenin A5 119509-24-9 Membrane transporter/Ion channel Potassium Channel preconditioning sensitive mKATP Atpenin A 5 ischemia potassium complex II Inhibitor cardioprotective channel mitochondrial KcsA ATP inhibit reperfusion Atpenin A-5 inhibitor