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Afoxolaner

Catalog No. T13536 CAS 1093861-60-9

Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.

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Afoxolaner, CAS 1093861-60-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 36.00
10 mg	In stock	$ 61.00
25 mg	In stock	$ 117.00
50 mg	In stock	$ 191.00
100 mg	In stock	$ 298.00
1 mL * 10 mM (in DMSO)	In stock	$ 51.00

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Purity: 99.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.
In vivo	A single oral administration of afoxolaner at a dose near the minimum effective (2.5mg/kg) eradicated existing I. scapularis tick infestations and managed weekly re-infestations effectively. Efficiencies ranged from 98% to 100% up to Day 23 and remained at 94% on Day 30 [1].

Molecular Weight	625.87
Formula	C26H17ClF9N3O3
CAS No.	1093861-60-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: ≥ 250 mg/mL (399.44 mM)

References and Literature

1. Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol. 2014 Apr 2;201(3-4):223-5. 2. Beugnet F, et al. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs.Parasite. 2014;21:42.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Membrane Protein-targeted Compound Library Anti-Infection Compound Library Human Metabolite Library Anti-Parkinson's Disease Compound Library Neuronal Signaling Compound Library Ion Channel Inhibitor Library Bioactive Compounds Library Max

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NPPB Talniflumate Irisolidone Betaine chloride Shikonin T16Ainh-A01 Flufenamic acid Selamectin

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Keywords

Afoxolaner 1093861-60-9 Membrane transporter/Ion channel Microbiology/Virology Neuroscience GABA Receptor Chloride channel Parasite acaricide isoxazoline Inhibitor arthropod Cl? Channels scapularis dog γ-Aminobutyric acid Receptor Chloride Channel insecticide inhibit insect Gamma-aminobutyric acid Receptor Ixodes inhibitor

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