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Acyclovir

Catalog No. T1454   CAS 59277-89-3
Synonyms: Aciclovir, Acycloguanosine, 阿昔洛韦

Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.

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Acyclovir, CAS 59277-89-3
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.
Targets&IC50 HSV-2:0.86 μM (IC50), HSV-1:0.85 μM (IC50)
In vitro Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains[2].
In vivo low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections[3].
Kinase Assay Total AMPK activity is measured using the method of Dagher et al. AMPK activity is quantified in the resuspended pellet as incorporation of?32P from [γ-32P]ATP (10 GBq/mmol) into a synthetic peptide with the specific target sequence for AMPK, the SAMS peptide. Radioactivity is measured using a liquid scintillation counter. Protein content in the solution containing the resupended (NH4)2SO4 pellet is determined using the Bradford method.
Synonyms Aciclovir, Acycloguanosine, 阿昔洛韦
Molecular Weight 225.208
Formula C8H11N5O3
CAS No. 59277-89-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45 mg/mL (199.82 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Meyrick Thomas RH, et al. Br J Dermatol. 1985, 113(6):731-735. 2. Collins P, et al. J Antimicrob Chemother. 1986, 18 Suppl B:103-12. 3. Tang IY, et al. Transplant Proc. 1989, 21(1 Pt 2):1758-1760. 4. Wang C, Guan Y, Lv M, et al. manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses[J]. Immunity. 2018 Apr 17;48(4):675-687.e7.

Citations

1. Wang C, Guan Y, Lv M, et al. Manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses. Immunity. 2018, 48(4): 675-687. e7

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Antibiotics Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Nucleotide Compound Library DNA Damage & Repair Compound Library Immunology/Inflammation Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library

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Keywords

Acyclovir 59277-89-3 DNA损伤和修复 凋亡 微生物学 细胞周期 Antibacterial Antibiotic Apoptosis DNA/RNA Synthesis HSV inhibit Inhibitor Herpes simplex virus thymidine triphosphate immunosuppression DNA Aciclovir anti-herpetic Acycloguanosine kinase antibody polymerase Bacterial inhibitor