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Acyclovir

Catalog No. T1454 CAS 59277-89-3

Synonyms: Aciclovir, Acycloguanosine

Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.

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Acyclovir, CAS 59277-89-3

Pack Size	Availability	Price/USD
25 mg	In stock	$ 39.00
50 mg	In stock	$ 51.00
100 mg	In stock	$ 80.00
200 mg	In stock	$ 104.00
500 mg	In stock	$ 131.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100.00%

Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.
Targets&IC50	HSV2:0.86 μM (IC50), HSV1:0.85 μM (IC50)
In vitro	Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains[2].
In vivo	low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections[3].
Kinase Assay	Total AMPK activity is measured using the method of Dagher et al. AMPK activity is quantified in the resuspended pellet as incorporation of?32P from [γ-32P]ATP (10 GBq/mmol) into a synthetic peptide with the specific target sequence for AMPK, the SAMS peptide. Radioactivity is measured using a liquid scintillation counter. Protein content in the solution containing the resupended (NH4)2SO4 pellet is determined using the Bradford method.

Synonyms	Aciclovir, Acycloguanosine
Molecular Weight	225.2
Formula	C8H11N5O3
CAS No.	59277-89-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (199.82 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Meyrick Thomas RH, et al. Br J Dermatol. 1985, 113(6):731-735. 2. Collins P, et al. J Antimicrob Chemother. 1986, 18 Suppl B:103-12. 3. Tang IY, et al. Transplant Proc. 1989, 21(1 Pt 2):1758-1760. 4. Wang C, Guan Y, Lv M, et al. manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses[J]. Immunity. 2018 Apr 17;48(4):675-687.e7.

Citations

1. Wang C, Guan Y, Lv M, et al. Manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses. Immunity. 2018, 48(4): 675-687. e7

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Clinical Compound Library DNA Damage & Repair Compound Library Immunology/Inflammation Compound Library Approved Drug Library Anti-COVID-19 Compound Library FDA-Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Acyclovir 59277-89-3 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology DNA/RNA Synthesis Antibacterial Antibiotic HSV inhibit Inhibitor Herpes simplex virus thymidine triphosphate immunosuppression DNA anti-herpetic kinase Aciclovir antibody polymerase Acycloguanosine Bacterial inhibitor

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