Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.
Description | Acyclovir is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. |
Targets&IC50 | HSV-1:0.85 μM (IC50), HSV-2:0.86 μM (IC50) |
In vitro | Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains[2]. |
In vivo | low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections[3]. |
Kinase Assay | Total AMPK activity is measured using the method of Dagher et al. AMPK activity is quantified in the resuspended pellet as incorporation of?32P from [γ-32P]ATP (10 GBq/mmol) into a synthetic peptide with the specific target sequence for AMPK, the SAMS peptide. Radioactivity is measured using a liquid scintillation counter. Protein content in the solution containing the resupended (NH4)2SO4 pellet is determined using the Bradford method. |
Synonyms | Aciclovir, Acycloguanosine |
Molecular Weight | 225.21 |
Formula | C8H11N5O3 |
CAS No. | 59277-89-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 45 mg/mL (199.82 mM)
Ethanol: <1 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Acyclovir 59277-89-3 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology HSV Antibacterial Antibiotic DNA/RNA Synthesis inhibit Inhibitor Herpes simplex virus thymidine triphosphate immunosuppression DNA Aciclovir anti-herpetic Acycloguanosine kinase antibody polymerase Bacterial inhibitor