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AS-041164

Catalog No. T21938 CAS 6318-41-8

AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory effects.

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AS-041164, CAS 6318-41-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 123.00
50 mg	In stock	$ 227.00
100 mg	In stock	$ 365.00
200 mg	In stock	$ 483.00
500 mg	In stock	$ 789.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.59%

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Storage & Solubility Information

Description	AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory effects.
Targets&IC50	PI3Kγ:70 nM, PI3Kα:240 nM, PI3Kβ:1.4 μM, PI3Kδ:1.7 μM
In vivo	AS-041164 (3-100 mg/kg p.o.) treatment dose-dependently decreases r-h regulated on activation normal T cell expressed and secreted (RANTES)-induced neutrophil recruitment in mice.?The ED50 value for AS-041164 is 27.35 mg/kg.?AS-041164 blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation.?AS-041164 (10-100 mg/kg; oral administration; once) treatment results in the reduction of inflammatory swelling in the model of carrageenan-induced paw edema.

Molecular Weight	249.24
Formula	C11H7NO4S
CAS No.	6318-41-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (501.52 mM), Sonication is recommended.

References and Literature

1. Chiara Ferrandi, et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther. 2007 Sep;322(3):923-30.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Anti-Breast Cancer Compound Library Anti-Cancer Metabolism Compound Library Reprogramming Compound Library Orally Active Compound Library NO PAINS Compound Library Anti-Obesity Compound Library Stem Cell Differentiation Compound Library Antioxidant Compound Library

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Keywords

AS-041164 6318-41-8 PI3K/Akt/mTOR signaling PI3K Inhibitor PI3Kγ inhibit AS041164 Phosphoinositide 3-kinase anti-inflammatory neutrophil recruitment RANTES AS 041164 inhibitor

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