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AM580

Catalog No. T5854 CAS 102121-60-8

Synonyms: NSC608001, CD336, Ro 40-6055

AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )

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AM580, CAS 102121-60-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 33.00
5 mg	In stock	$ 52.00
10 mg	In stock	$ 79.00
25 mg	In stock	$ 167.00
50 mg	In stock	$ 333.00
100 mg	In stock	$ 493.00
500 mg	In stock	$ 1,120.00
1 mL * 10 mM (in DMSO)	In stock	$ 58.00

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Purity: 99.89%

Purity: 98%

Biological Description

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Description	AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
In vitro	AM580 can inhibit the proliferation of various tumor cells,inhibiting survival signaling pathways and inducing apoptosis[1].
In vivo	Modulation of the RARα/β to RARγ expression in mammary glands of normal mice, oncomice, and human mammary cell lines through the alteration of RAR-target gene expression affected cell proliferation, survival and tumor growth.?Treatment of MMTV-Myc mice with the RARα-selective agonist Am580 led to significant inhibition of mammary tumor growth (~90%, P<0.001), lung metastasis (P<0.01) and extended tumor latency in 63% of mice.?In these mice, RARα responsive genes such as Cyp26A1, E-cadherin, cellular retinol-binding protein 1 (CRBP1) and p27, were up-regulated[2].
Cell Research	Ishikawa cells were transfected with control siRNA or siRNA specific against the RARα gene.Cells were treated with vehicle control or AM580 for 18 h.Cells were stained with trypan blue and counted[1].
Animal Research	The effects of c-Myc on RAR isotype expression were evaluated in normal mouse mammary epithelium, mammary tumor cells obtained from the MMTV-Myc transgenic mouse model as well as human normal immortalized breast epithelial and breast cancer cell lines.?The in vivo effect of the RARα-selective agonist 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carboxamido]benzoic acid (Am580) was examined in the MMTV-Myc mouse model of mammary tumorigenesis[2].

Synonyms	NSC608001, CD336, Ro 40-6055
Molecular Weight	351.44
Formula	C22H25NO3
CAS No.	102121-60-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (128.04 mM)

References and Literature

1. Cheng Y H , Utsunomiya H , Pavone M E , et al. Retinoic acid inhibits endometrial cancer cell growth via multiple genomic mechanisms[J]. Journal of Molecular Endocrinology, 2011, 46(2):139-153. 2. Bosch A , Bertran S P , Lu Y , et al. Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis[J]. Breast Cancer Research,14,4(2012-08-24), 2012, 14(4).

Related compound libraries

This product is contained In the following compound libraries：

Target-Focused Phenotypic Screening Library Metabolism Compound Library Anti-Aging Compound Library Lipid Metabolism Compound Library Immunology/Inflammation Compound Library ReFRAME Related Library Nuclear Receptor Compound Library Bioactive Compounds Library Max Autophagy Compound Library Neuronal Differentiation Compound Library

Related Products

Related compounds with same targets

Cecropin B acetate Ro 41-5253 Ch55 TTNPB Isotretinoin LY 178002 trifarotene Retinoic acid

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AM580 102121-60-8 Autophagy Metabolism Retinoid Receptor inhibit Inhibitor NSC-608001 CD-336 Retinoic acid receptors AM 580 RAR/RXR AM-580 NSC608001 CD336 NSC 608001 Retinoid X receptors Ro 40-6055 CD 336 inhibitor

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