a-3 hydrochloride

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1], and also inhibits PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM), and myosin light chain kinase (MLCK) (Ki=7.4 μM).

ATB107 hydrochloride is a novel and potent inhibitor of indole-3-glycerol phosphate synthase (IGPS) with a KD of 3 μM.

CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 µM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer [1].

5-[(1S,2S)-2-[(Cyclopropylmethyl)amino]cyclopropyl]-N-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxamide hydrochloride is a cyclopropanoid enzyme compound that acts as a lysine-specific demethylase-1 inhibitor for schizophrenia, developmental disorders, and neurodegenerative diseases.

N-0500 HCl ((-)-Propyl-9-hydroxynaphthoxazine Hydrochloride) is a very potent centrally acting DA receptor agonist. N-0500 HCl is a potent displacer of the specific [3H]DP-5,6-ADTN binding with IC50 of 3 nM.

Benzoquinamide hydrochloride (3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride) is an antiemetic agent and increases intra-arterial pressure due to the increased peripheral vascular resistance.

4-Amino-3-chlorophenol hydrochloride ,with CAS No. 52671-64-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Amino-3-chlorophenol hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-(Benzyloxy)-1-ethanamine hydrochloride ,with CAS No. 10578-75-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-(Benzyloxy)-1-ethanamine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-(Trifluoromethyl)aniline hydrochloride ,with CAS No. 2646-97-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-(Trifluoromethyl)aniline hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Hydroxypiperidine hydrochloride ,with CAS No. 64051-79-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Hydroxypiperidine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Methyl 3-(aminomethyl)benzoate hydrochloride ,with CAS No. 17841-68-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Methyl 3-(aminomethyl)benzoate hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-AMinoMethyl-3-fluoropyridine hydrochloride, with CAS No. 312904-49-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-AMinoMethyl-3-fluoropyridine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride, with CAS No. 42718-18-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Azabicyclo[3.3.0]octane hydrochloride ,with CAS No. 112626-50-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Azabicyclo[3.3.0]octane hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Aminobenzoic acid hydrochloride ,with CAS No. 15151-51-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Aminobenzoic acid hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Amino-2,6-piperidinedione hydrochloride ,with CAS No. 2686-86-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Amino-2,6-piperidinedione hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-Methylpiperidine-4-carboxylic acid hydrochloride ,with CAS No. 71985-80-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-Methylpiperidine-4-carboxylic acid hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride ,with CAS No. 84163-13-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.

Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels.

Granisetron hydrochloride (Granisetron HCl) is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.

Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic piperazine derivative with hypotensive antiadrenergic properties, It is used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention.

Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochloride can cause both an acute hepatitis-like syndrome occurring within 1 to 3 months of starting therapy or a more insidious chronic hepatitis with autoimmune features typically after long-term treatment.

Tropisetron hydrochloride (Tropisetron HCl) is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, with antinauseant and antiemetic activities.