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4-PPBP maleate

Catalog No. T22513 CAS 201216-39-9

4-PPBP maleate is a potent σ1 receptor (ligand) agonist. 4-PPBP maleate can be considered a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression. 4-PPBP maleate has neuroprotective properties.

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4-PPBP maleate, CAS 201216-39-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 68.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 549.00
500 mg	In stock	$ 1,170.00
1 mL * 10 mM (in DMSO)	In stock	$ 85.00

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Purity: 99.54%

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Storage & Solubility Information

Description	4-PPBP maleate is a potent σ1 receptor (ligand) agonist. 4-PPBP maleate can be considered a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression. 4-PPBP maleate has neuroprotective properties.
In vitro	ERK1/2 phosphorylation is induced by 4-PPBP maleate in primary neurons.[3]
In vivo	In rats, administration of 4-PPBP maleate (1 μmol/kg; i.v.) leads to a reduction in brain injury following transient focal ischemia.[2]

Molecular Weight	409.52
Formula	C25H31NO4
CAS No.	201216-39-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 10.24 mg/mL

DMSO: 225.0 mg/mL (549.4 mM), Sonication is recommended.

References and Literature

1. Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282(1):326-338. 2. Takahashi H, et al. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke. 1996;27(11):2120-2123. 3. Tan F, et al. The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action. Neuropharmacology. 2010;59(6):416-424.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Bioactive Compound Library Neuronal Signaling Compound Library

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Keywords

4-PPBP maleate 201216-39-9 GPCR/G Protein Neuroscience NMDAR Sigma receptor 4PPBP maleate 4-PPBP Maleate 4 PPBP maleate inhibitor inhibit

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