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17α-Hydroxyprogesterone

Catalog No. T1429   CAS 68-96-2
Synonyms: Hydroxyprogesterone, 17-OHP, 17-Hydroxyprogesterone

17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.

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17α-Hydroxyprogesterone Chemical Structure
17α-Hydroxyprogesterone, CAS 68-96-2
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1 g In stock $ 25.00
1 mL * 10 mM (in DMSO) In stock $ 28.00
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Purity: 99.79%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.
In vitro 17α-OHP is an agonist of the progesterone receptor (PR) similarly to progesterone, albeit weakly in comparison[1]. It is a chemical intermediate in the biosynthesis of steroid hormones, including the androgen and estrogen sex hormones and the glucocorticoids and mineralocorticoids.
In vivo 17-Hydroxyprogesterone is a potent steroid inducer of GVBD (germinal vesicle breakdown)[3].
Synonyms Hydroxyprogesterone, 17-OHP, 17-Hydroxyprogesterone
Molecular Weight 330.46
Formula C21H30O3
CAS No. 68-96-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 38 mg/mL (115 mM)

Ethanol: 61 mg/mL (184.6 mM)

TargetMolReferences and Literature

1. Fatihah SN, et al. Pak J Biol Sci. 2014, 17(10):1124-9. 2. BJ Attardi, et al. Am J Obstet Gynecol. 2007, 197(6):599.e1-7. 3. B. Mojazi Amiri, et al. J Agric Sci Technol. 2001, 3: 199-207.

Related compound libraries

This product is contained In the following compound libraries:
Human Endogenous Metabolite Library FDA-Approved Drug Library Bioactive Compounds Library Max Bioactive Lipid Compound Library NO PAINS Compound Library Polyphenolic Natural Product Library Nuclear Receptor Compound Library Flavonoid Natural Product Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library

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Keywords

17α-Hydroxyprogesterone 68-96-2 Endocrinology/Hormones Metabolism Others Estrogen/progestogen Receptor Progesterone Receptor Endogenous Metabolite 17alpha-Hydroxyprogesterone Hydroxyprogesterone NR3C3 17-OHP Inhibitor 17-Hydroxyprogesterone inhibit 17a-Hydroxyprogesterone 17α Hydroxyprogesterone 17αHydroxyprogesterone inhibitor

 

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