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11-Beta-hydroxyandrostenedione

Catalog No. T14001 CAS 382-44-5

Synonyms: NSC-17102, 4-Androsten-11β-ol-3,17-dione

11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases.

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11-Beta-hydroxyandrostenedione Chemical Structure

11-Beta-hydroxyandrostenedione, CAS 382-44-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 128.00
50 mg	In stock	$ 208.00
100 mg	In stock	$ 313.00
500 mg	In stock	$ 753.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 98.96%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases.
In vitro	21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) are assayed within the LNCaP cell line to establish that this conversion is catalyzed by the lyase activity of CYP17A1. After the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF, and 21dE are in fact metabolized to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively [2].
In vivo	In 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high. In congenital 11-hydroxylase deficiency and adrenal insufficiency, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very low. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism [1].

Synonyms	NSC-17102, 4-Androsten-11β-ol-3,17-dione
Molecular Weight	302.41
Formula	C19H26O3
CAS No.	382-44-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (826.69 mM), Sonication is recommended.

References and Literature

1. Ibrahim F, et al. Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer. J Steroid Biochem Mol Biol. 2003 Apr;84(5):563-8. 2. Rachelle Gent, et al. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17αhydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Human Endogenous Metabolite Library Human Endogenous Metabolite Compound Library Plus NO PAINS Compound Library Mouse Metabolite Compound Library RO5 Drug-like Natural Product Library Human Metabolite Library ReFRAME Related Library Natural Product Library for HTS Natural Product Library

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Keywords

11-Beta-hydroxyandrostenedione 382-44-5 Metabolism Endogenous Metabolite 11Betahydroxyandrostenedione inhibit 4-androstenedione Cushing's hyperandrogenism adrenal syndrome NSC-17102 Inhibitor NSC17102 4-Androsten-11b-ol-3,17-dione 4-Androsten-11β-ol-3,17-dione 4-Androsten-11beta-ol-3,17-dione NSC 17102 steroid 11-β-hydroxyandrostenedione 11 Beta hydroxyandrostenedione 11-b-hydroxyandrostenedione 11β-hydroxylase ovarian inhibitor

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