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(R)-Propranolol hydrochloride

Name: (R)-Propranolol hydrochloride
Brand: TargetMol
SKU: T20898
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20898Cas No. 13071-11-9

Alias Dexpropranolol hydrochloride, (R)-(+)-Propranolol

(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.

(R)-Propranolol hydrochloride

🥰Excellent

Purity: 99.01%

Catalog No. T20898Alias Dexpropranolol hydrochloride, (R)-(+)-PropranololCas No. 13071-11-9

Pack Size	Price	Availability
25 mg	$35	In Stock
50 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.01%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.
Targets&IC50	β2-adrenoceptor:0.8 nM(Ki), β1-adrenoceptor:1.8 nM(Ki)
In vivo	Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane and reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs, but the dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species[4]. Administration of 10 mg/kg (R)-Propranolol hydrochloride has no antagonistic activity in rats, the cardiac responses to isoprenaline of rats can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation[4].
Synonyms	Dexpropranolol hydrochloride, (R)-(+)-Propranolol

Chemical Properties

Molecular Weight	295.8
Formula	C₁₆H₂₂ClNO₂
Cas No.	13071-11-9
Smiles	Cl.CC(C)NC[C@@H](O)COc1cccc2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 14.79 mg/mL (50 mM), Sonication is recommended.

DMSO: 60 mg/mL (202.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3807 mL	16.9033 mL	33.8066 mL	169.0331 mL
5 mM	0.6761 mL	3.3807 mL	6.7613 mL	33.8066 mL
10 mM	0.3381 mL	1.6903 mL	3.3807 mL	16.9033 mL
20 mM	0.1690 mL	0.8452 mL	1.6903 mL	8.4517 mL
50 mM	0.0676 mL	0.3381 mL	0.6761 mL	3.3807 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0338 mL	0.1690 mL	0.3381 mL	1.6903 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc