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(S)-(-)-Bay-K-8644

Catalog No. TQ0144 CAS 98625-26-4

Synonyms: (S)-(-)-Bay K 8644

(S)-(-)-Bay-K-8644 ((S)-(-)-Bay K 8644) is an agonist of L-type Ca2+ channel and activates Ba2+ currents with an EC50 of 32 nM.

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(S)-(-)-Bay-K-8644, CAS 98625-26-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 66.00
2 mg	In stock	$ 94.00
5 mg	In stock	$ 145.00
10 mg	In stock	$ 195.00
25 mg	In stock	$ 423.00
50 mg	In stock	$ 646.00
1 mL * 10 mM (in DMSO)	In stock	$ 159.00

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Purity: 98.28%

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Description	(S)-(-)-Bay-K-8644 ((S)-(-)-Bay K 8644) is an agonist of L-type Ca2+ channel and activates Ba2+ currents with an EC50 of 32 nM.
Targets&IC50	Ba2+ current:32 nM (EC50)
In vitro	The Ca2+ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca2+ channels [1]. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC50: 14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176 [2]. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum [3].

Synonyms	(S)-(-)-Bay K 8644
Molecular Weight	356.3
Formula	C16H15F3N2O4
CAS No.	98625-26-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 0.1 mg/mL (insoluble), Sonification and heating to 60℃ are recommended.

DMSO: 120 mg/mL (336.79 mM), Sonification is recommended.

References and Literature

1. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15. 2. Rampe D, et al. Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle. Mol Pharmacol. 1992 Apr;41(4):599-602. 3. Mironov SL, et al. L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 ( Pt 1):75-87.

Related compound libraries

This product is contained In the following compound libraries：

Ion Channel Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Metabolism Compound Library

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Keywords

(S)-(-)-Bay-K-8644 98625-26-4 Membrane transporter/Ion channel Metabolism Calcium Channel Ca channels Bay K8644 Inhibitor (S)-(-)-Bay K 8644 (S) ( ) Bay K 8644 Bay K 8644 Bay K-8644 inhibit (S)()BayK8644 Bay-K 8644 Bay-K8644 Ca2+ channels Bay-K-8644 inhibitor

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