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(-)-Epicatechin gallate

Catalog No. T2732   CAS 1257-08-5
Synonyms: (−)-Epicatechin 3-gallate, Epicatechin gallate, (-)-Epicatechin 3-gallate, (-)-Epicatechin 3-O-gallate, ECG

(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) is one of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin A (gA) channels as probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency. The gallate group causes current block, as evident by brief downward current transitions.

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(-)-Epicatechin gallate Chemical Structure
(-)-Epicatechin gallate, CAS 1257-08-5
Pack Size Availability Price/USD Quantity
20 mg In stock $ 50.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.72%
Purity: 99.16%
Purity: 98.97%
Purity: 96.65%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) is one of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin A (gA) channels as probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency. The gallate group causes current block, as evident by brief downward current transitions.
Targets&IC50 COX-1:7.5 μM.
Source
Synonyms (−)-Epicatechin 3-gallate, Epicatechin gallate, (-)-Epicatechin 3-gallate, (-)-Epicatechin 3-O-gallate, ECG
Molecular Weight 442.37
Formula C22H18O10
CAS No. 1257-08-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (124.33 mM)

H2O: 2.5 mg/mL (5.65 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Rosado H, et al. Int J Mol Sci. 2015 Jul 23;16(8):16710-27. 2. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet[J]. Planta medica. 2019.

TargetMolCitations

1. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-1135 2. Zhao Y, Li Y, Zhu R, et al.RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m6A modification.Signal Transduction and Targeted Therapy.2023, 8(1): 224.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Natural Product Library for HTS Natural Product Library Drug Repurposing Compound Library Traditional Chinese Medicine Monomer Library Anti-Cancer Drug Library Flavonoid Natural Product Library Tibetan medicine Compound Library Food as Medicine Compound Library Anti-Infection Compound Library

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Keywords

(-)-Epicatechin gallate 1257-08-5 Autophagy Immunology/Inflammation Microbiology/Virology Neuroscience Virus Protease COX Inhibitor inhibit Cyclooxygenase ()Epicatechin gallate (−)-Epicatechin 3-gallate Epicatechin gallate (-)-Epicatechin 3-gallate Epicatechin 3-O-gallate Epicatechin 3-gallate (-)-Epicatechin 3-O-gallate ( ) Epicatechin gallate ECG inhibitor

 

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