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λ-Cyhalothrin

Catalog No. T27794 CAS 91465-08-6

Synonyms: lambda-Cyhalothrin, Karate, Icon

λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group. It is employed across various applications for controlling a wide array of pests. As a neurotoxin, λ-Cyhalothrin acts on sodium channels in neuron membranes within the central nervous system.

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λ-Cyhalothrin, CAS 91465-08-6

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 41.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.94%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group. It is employed across various applications for controlling a wide array of pests. As a neurotoxin, λ-Cyhalothrin acts on sodium channels in neuron membranes within the central nervous system.
In vitro	λ-Cyhalothrin's toxicity mechanism involves delaying sodium channel inactivation, leading to prolonged depolarization of the nerve membrane. This compound causes membrane depolarization, influx of calcium ions, and neurotransmitter release in rat brain synaptosomes[1]. Additionally, λ-Cyhalothrin exhibits estrogenic qualities, acting as a xenoestrogen that promotes proliferation of human breast carcinoma cells in vitro[1]. It is extensively utilized for controlling pests (fleas, cockroaches, flies, and ants)[1] and is highly effective against Anopheles species, known for transmitting malaria[1].
In vivo	The investigation assesses the impact of λ-Cyhalothrin (i.p.) on memory, movement activity, and coordination in mice subjected to bilateral clamping of the carotid arteries (BCCA). It was found that neither memory nor coordination was negatively affected by BCCA or λ-Cyhalothrin. However, a notable decline in exploratory locomotor activity was observed in the BCCA/LCH group, and spontaneous movement activity significantly decreased in the BCCA/λ-Cyhalothrin group. Furthermore, when exposed to λ-Cyhalothrin in the presence of BCCA, a decrease in motor activity was evident in mice during two subsequent 30-minute sessions[1].

Synonyms	lambda-Cyhalothrin, Karate, Icon
Molecular Weight	449.85
Formula	C23H19ClF3NO3
CAS No.	91465-08-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (66.69 mM), Sonication is recommended.

References and Literature

1. Barbara Nieradko-Iwanicka, et al. Effect of Lambda-Cyhalothrin on Memory and Movement in Mice After Transient Incomplete Cerebral Ischemia. Ann Agric Environ Med. 2011;18(1):41-5. 2. Shen X, Xu Z, Zhang X, Yang F. Stable carbon isotope fractionation during the biodegradation of lambda-cyhalothrin. Sci Total Environ. 2015 Nov 1;532:415-9. doi: 10.1016/j.scitotenv.2015.05.045. Epub 2015 Jun 16. PubMed PMID: 26092290. 3. Elhalwagy ME, Abd-Alrahman SH, Nahas AA, Ziada RM, Mohamady AH. Hepatopancreatic intoxication of lambda cyhalothrin insecticide on albino rats. Int J Clin Exp Med. 2015 May 15;8(5):7297-305. eCollection 2015. PubMed PMID: 26221269; PubMed Central PMCID: PMC4509214. 4. Abbas N, Shad SA. Assessment of resistance risk to lambda-cyhalothrin and cross-resistance to four other insecticides in the house fly, Musca domestica L. (Diptera: Muscidae). Parasitol Res. 2015 Jul;114(7):2629-37. doi: 10.1007/s00436-015-4467-2. Epub 2015 Apr 23. PubMed PMID: 25903007. 5. Piner P, Üner N. Neurotoxic effects of lambda-cyhalothrin modulated by piperonyl butoxide in the brain of Oreochromis niloticus. Environ Toxicol. 2014 Nov;29(11):1275-82. doi: 10.1002/tox.21858. Epub 2013 Mar 5. PubMed PMID: 23460558.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Bioactive Compound Library Ion Channel Inhibitor Library NO PAINS Compound Library Anti-Cancer Compound Library Anti-Infection Compound Library Bioactive Compounds Library Max Sodium Channel Blocker Library

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Keywords

λ-Cyhalothrin 91465-08-6 Membrane transporter/Ion channel Microbiology/Virology Sodium Channel Parasite Na channels Inhibitor λ Cyhalothrin Na+ channels inhibit lambda-Cyhalothrin depolarization λCyhalothrin Karate pesticide pyrethroid choreoatetosis acaricide Insecticide neurotoxin salivation Icon α-cyano inhibitor

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