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α-Cyano-4-hydroxycinnamic acid

α-Cyano-4-hydroxycinnamic acid
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Purity:99.8%
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α-Cyano-4-hydroxycinnamic acid

Catalog No. T7460Cas No. 28166-41-8
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).
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Pack SizePrice/USDAvailabilityQuantity
50 mg$45In Stock
100 mg$64In Stock
200 mg$94In Stock
1 mL x 10 mM (in DMSO)$39In Stock
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Product Introduction

Bioactivity
Description
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).
In vitro
The effectiveness of CHC in glioma cells appears to be dependent on Monocarboxylate transporters (MCTs) membrane expression.?MCT1 downregulation showed similar effects on different glioma cells, supporting CHC as an MCT1 inhibitor.?There was a synergistic effect when combining CHC with temozolomide treatment in U251 cells.?In the CAM in vivo model, CHC decreased the size of tumors and the number of blood vessels formed[1].
Cell Research
Cells were plated into 96-well plates, at a density of 3 × 10^3 cells per well.?The effect of treatment with CHC (0.6–12 mM) on cell number (total biomass) was determined at 24, 48, and 72 h by the?sulforhodamine B assay (SRB, TOX-6).?IC50 values (CHC concentration that corresponds to 50% of cell growth inhibition) were estimated from 3 independent experiments, each one in triplicate, using GraphPad Software.?Cell proliferation assay was performed as previously described32 and assessed under the treatment conditions previously described, for 5 mM and 10 mM of CHC.?After CHC treatment, cells were incubated with BrdU and its incorporation was assessed at 450 nm (λref = 655 nm) .?Cell growth (total biomass) and cell proliferation for glioma siMCT1 cells and the effect of CHC (1.25–15 mM) on cell number were performed[1].
Aliasα-Cyano-4-hydroxycinnamic acid(α-CHCA)
Chemical Properties
Molecular Weight189.17
FormulaC10H7NO3
Cas No.28166-41-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 37mg/mL(195.59mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.2863 mL26.4313 mL52.8625 mL264.3125 mL
5 mM1.0573 mL5.2863 mL10.5725 mL52.8625 mL
10 mM0.5286 mL2.6431 mL5.2863 mL26.4313 mL
20 mM0.2643 mL1.3216 mL2.6431 mL13.2156 mL
50 mM0.1057 mL0.5286 mL1.0573 mL5.2863 mL
100 mM0.0529 mL0.2643 mL0.5286 mL2.6431 mL

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