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3,3'-Diindolylmethane

Catalog No. T2991 CAS 1968-05-4

Synonyms: HB 236, DIM, Arundine

3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.

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3,3'-Diindolylmethane Chemical Structure

3,3'-Diindolylmethane, CAS 1968-05-4

Pack Size	Availability	Price/USD
50 mg	In stock	$ 39.00
100 mg	In stock	$ 53.00
200 mg	In stock	$ 62.00
500 mg	In stock	$ 81.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 100%

Biological Description

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Description	3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.
In vitro	DIM is a potent radioprotector and mitigator that functions by stimulating an ATM-driven DDR-like response and NF-κB survival signaling. DIM can inhibit invasion, angiogenesis, and proliferation and induce apoptosis in tumor cells by modulating signaling pathways involving AKT, NF-κB, and FOXO3. It can also inhibit estrogen-inducible gene expression and cause an endoplasmic reticulum stress response. DIM alters estrogen metabolism by shifting metabolism from carcinogenic 16α-hydroxy to inert 2-hydroxy derivatives, and it antagonizes estrogen and androgen receptor activity[1].
In vivo	Preliminary studies show DIM is most effective against total body irradiation (TBI) when given in multiple once-daily doses. Treatment of DIM has radioprotection and mitigation properties in vivo. DIM Activates ATM in Normal Tissues. DIM can be given to mice (250 mg/kg) by oral gavage, with no acute toxicity and excellent bioavailability[1].
Cell Research	The 184A1 and Hs578Bst cells are pretreated with DIM (0.3 μM) or vehicle for 24 h, irradiated by using different doses of 137Cs γ rays, harvested, plated at different densities, incubated for 14 d, and counted for colony formation.(Only for Reference)

Synonyms	HB 236, DIM, Arundine
Molecular Weight	246.31
Formula	C17H14N2
CAS No.	1968-05-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 18 mg/mL (73.08 mM)

DMSO: 24.6 mg/mL(100 mM)

References and Literature

1. Saijun Fan, et al. PNAS. 2013, 110(46):18650-18655.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Drug Library Human Metabolite Library Bioactive Compounds Library Max Natural Product Library for HTS ReFRAME Related Library Anti-Prostate Cancer Compound Library Clinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

3,3'-Diindolylmethane 1968-05-4 Autophagy Endocrinology/Hormones Androgen Receptor HB 236 Inhibitor 3,3' Diindolylmethane HB-236 DIM HB236 3,3'Diindolylmethane inhibit Arundine inhibitor

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