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Search Results for " spla2 "

Targets

19

Compounds

2

Natural Products

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T12990 sPLA2-X Inhibitor 31 Others
sPLA2-X Inhibitor 31 is a selective inhibitor of secreted phospholipase A2 type X (sPLA2-X) (IC50s of 26 nM, 310 nM, and 2230 nM for sPLA2-X, sPLA2-IIa, and sPLA2-V, respectively).
T27731 sPLA2 inhibitor 1 KH-064,KH 064,KH064,5-BPP acid
KH064 is a sPLA2-IIA inhibitor of oral activity.
T81115 sPLA2-IIA Inhibitor
The sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK, specifically cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2), which interacts with human IIA phospholipase A2 (hGIIA) to impede its ester bond hydrolyzing function. A...
T2044 Varespladib LY315920 Phospholipase
Varespladib (LY315920), a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the treatment and prevention of sickle cell disease, vaso-occlusiv...
T39173 Varespladib sodium LY315920 sodium
Varespladib sodium (LY315920 sodium) is a highly potent and selective inhibitor of group IIA secretory phospholipase A2 (sPLA2), with an IC50 of 9 nM. It demonstrates significant inhibitory activity against sPLA2 in seru...
T22950 LY-311727 LY 311727 Others
secreted phospholipase A2 (sPLA2) inhibitor
T23547 YM 26734 Others
Competitive inhibitor of secretory phospholipase A2 (sPLA2)
T25787 Me-Indoxam Methyl indoxam,Methyl-indoxam
Me-Indoxam is an inhibitor of sPLA2. It has no effect on arachidonic acid release and platelet activating factor synthesis.
T61168 CAY10590
CAY10590 (GK115) is a compound that functions as an inhibitor of secreted phospholipase A2 (sPLA2). It is commonly employed in research related to chronic inflammatory kidney diseases [1].
T37580 Arachidonoyl thio-PC
Arachidonoyl Thio-PC is a substrate for many phospholipase A2s (PLA2s) including sPLA2, cPLA2, and iPLA2. Cleavage of the sn-2 fatty acid by PLA2 results in generation of a free thiol which reacts with chromogenic reagen...
T30831 Cgp 43182 Cgp-43182,Cgp43182
CGP 43182 is an effective inhibitor of group IIA secretory phospholipase A2 (Group IIA sPLA2) activity in vitro, which can be used to prevent the synergistic effect of pro-inflammatory genes stimulated by cytokines media...
T37221 GK187
GK187 is an inhibitor of Group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2), an enzyme involved in basal cell metabolism. It inhibits GVIA iPLA2 by 99.8% at 0.091 mole fraction in a mixed micelle activity assa...
T75589 Bitis Cornuta Venom
Bitis Cornuta (Many-horned Adder) Venom, sourced from Bitis Cornuta, comprises snake venom phospholipase A2 (sPLA2) toxins that exhibit anticoagulant properties by inhibiting the prothrombinase complex, consequently prom...
T37244 Palmitoyl thio-PC
Thioester analogs of glycerophospholipids, in combination with Ellman's reagent, are convenient colorimetric substrates for the measurement of phospholipase (PL) activity. Palmitoyl thio-PC is a chromogenic PLA2 substrat...
T37123 1,2-Dioctanoyl PC
Phosphatidylcholine (PC) species are a common class of phospholipids that comprise the mammalian cell membrane. 1,2-Dioctanoyl PC is a synthetic analog of natural phosphatidylcholine species containing saturated C8:O fat...
T37785 1-Palmitoyl-2-linoleoyl PE
Phosphatidylethanolamines are important components of cell membranes and biochemical pathways of fatty acid synthesis. 1-Palmitoyl-2-linoleoyl PE (PLPE) is one of the many phosphatidylethanolamines that may be present in...
T35622 FKGK 18
FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA...
T10168 5-HT1A modulator 1 5-HT1Amodulator1 Phospholipase , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
5-HT1A modulator 1 displays very high affinities for the 5-HT1A, α1-adrenergic receptor, and D2 receptor (IC50s = 2 nM, 10 nM, and 40 nM).
T22589 Asenapine hydrochloride Others
Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder.
Cat No. Product Name Synonyms Targets
T13206 Tris(2,4-di-tert-butylphenyl)phosphate Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate is a natural compound isolated from Vitex negundo L. with anti-inflammatory activity.
T2907 Tanshinone I Tanshinone A Phospholipase
Tanshinone I (Tanshinone A), an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04016 PLA2G2D Protein, Human, Recombinant (hFc) Human HEK293 Cells
PLA2G2D Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.5 kDa and the accession number is Q9UNK4.
TMPY-04912 PLA2G2A Protein, Mouse, Recombinant (His) Mouse P. pastoris (Yeast)
PLA2G2A Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 15.3 kDa and the accession number is P31482.
TMPY-01705 PLA2G2A Protein, Human, Recombinant (His) Human HEK293 Cells
PLA2G2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.4 kDa and the accession number is A0A024RA96.
TMPY-02181 PLA2G12B Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Group XIIB secretory phospholipase A2-like protein, also known as Group XIII secretory phospholipase A2-like protein, GXIII sPLA2-like, sPLA2-GXIIB, GXIIB, PLA2G13 and PLA2G12B, is a secreted protein that belongs to the ...
TMPY-02162 Phospholipase A2 IIE/PLA2G2E Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Group IIE secretory phospholipase A2, also known as GIIE sPLA2, sPLA2-IIE, Phosphatidylcholine 2-acylhydrolase 2E and PLA2G2E is a secreted protein that belongs to the phospholipase A2 family. Mammalian secretory phospho...
TargetMol