polymerase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T80644	DNA polymerase-IN-1		Antiviral , DNA/RNA Synthesis
	DNA polymerase-IN-1, a DNA polymerase inhibitor, exhibited antiproliferative activity against tumor cells with a half-inhibitory concentration (IC50) of 20.7 μM. DNA polymerase-IN-1 inhibited Taq DNA polymerase with an I...		Antiviral , DNA/RNA Synthesis
T79926	Poly(A) polymerase		DNA/RNA Synthesis
	Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3' end of RNA, a process that involves integrating ATP as AMP. This modification enhances RNA stability and augments mRNA translat...		DNA/RNA Synthesis
T79922	Taq DNA polymerase		DNA/RNA Synthesis
	Taq DNA polymerase is a thermostable enzyme utilized in polymerase chain reactions (PCR) to amplify DNA sequences [1].		DNA/RNA Synthesis
T79308	DNA polymerase-IN-3		DNA/RNA Synthesis
	DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications in proliferative disease research [1].		DNA/RNA Synthesis
T82536	DNA polymerase-IN-4
	DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, exhibits antiretroviral activity, achieving an IC50 of 134.22 μM [1].
T79307	DNA polymerase-IN-2		DNA/RNA Synthesis
	DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, demonstrates inhibitory activity towards Taq DNA polymerase, with an IC50 value of 48.25 μM, and holds potential for application in value-added disease research [1].		DNA/RNA Synthesis
T74631	RNA polymerase II-IN-2
	RNA polymerase II-IN-2 (compound 20iii), a potent inhibitor of RNA polymerase II (Pol II) with a K i value of 9.5 nM, demonstrates cytotoxicity against cancer cells, exhibiting toxicity levels 2 and 5 times higher than α...
T74765	Viral polymerase-IN-1 hydrochloride
	Viral polymerase-IN-1 hydrochloride, a derivative of Gemcitabine, effectively inhibits influenza A and B virus infections, demonstrating IC90 values ranging from 11.4 to 15.9 μM, and possesses activity against SARS-CoV-2...
T79923	T7 RNA polymerase		DNA/RNA Synthesis
	T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcription (IVT) of mRNA. This polymerase requires Mg 2+ and selects on...		DNA/RNA Synthesis
T74630	RNA polymerase II-IN-1		DNA/RNA Synthesis
	RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM. It exhibits heightened cytotoxicity towards cancer cells and reduced toxicity in normal cells...		DNA/RNA Synthesis
T22749	DR2313	DR 2313	PARP
	DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.		PARP
T6842	G007-LK		PARP , Wnt/beta-catenin
	G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.		PARP , Wnt/beta-catenin
T15639	K-756		PARP , Wnt/beta-catenin
	K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 and TNKS2 (IC50s: 31 and 36 nM, respectively).		PARP , Wnt/beta-catenin
T8964	G244-LM		Others , PARP
	G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling.		Others , PARP
T16761	RK-287107		Others , PARP
	RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).		Others , PARP
T21524	4-amino-1,8-Naphthalimide		PARP
	4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM		PARP
T1807	JW 55	JW55	PARP , Wnt/beta-catenin
	JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).		PARP , Wnt/beta-catenin
T3168	MN-64	MN64	Others , PARP , Wnt/beta-catenin
	MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.		Others , PARP , Wnt/beta-catenin
T8184	Fucosterol		PARP , Endogenous Metabolite , PPAR
	Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression.		PARP , Endogenous Metabolite , PPAR
T6197	PJ34		PARP
	PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.		PARP