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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13809 | P62-mediated mitophagy inducer | PMI | Mitophagy |
P62-mediated mitophagy inducer (PMI) is a regulator of mitophagy . | |||
T8970 | ML162 | Ferroptosis , GPX , Glutathione Peroxidase | |
ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively) | |||
T13360 | XRK3F2 | Autophagy | |
XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. | |||
T27709 | K67 | K 67,K-67 | |
K67 is a specific inhibitor against the interaction between KEAP1 DC domain and S349-phosphorylated KIR of p62/SQSTM1. | |||
T72560 | Antitumor agent-81 | ||
Antitumor agent-81, a P62-RNF168 agonist with low cytotoxicity, enhances the P62-RNF168 interaction, leading to decreased RNF168-mediated H2A ubiquitination and impaired homologous recombination-mediated DNA repair. Addi... | |||
T83945 | XIE62-1004 | ||
XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62. This interaction promotes p62 self-aggregation and its subsequent interaction with LC3 on autophagoso... | |||
T76040 | Dusquetide TFA | ||
Dusquetide (SGX942) TFA, a first-in-class innate defense regulator (IDR), modulates the innate immune response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) by interac... | |||
T76372 | TRAF6 peptide | ||
TRAF6 peptide, a specific TRAF6-p62 inhibitor, effectively inhibits NGF-dependent TrkA ubiquitination, showcasing strong research potential for neurological conditions including Alzheimer's disease (AD), Parkinson's, ALS... | |||
T78221 | TRAF6 peptide TFA | E1/E2/E3 Enzyme | |
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA. This peptide demonstrates promising research applications in various neurological disorde... | |||
T13667 | Dusquetide TFA (931395-42-5 free base) | SGX942 TFA,Dusquetide TFA | Others |
Dusquetide TFA is a kind of innate defense regulator (IDR).Dusquetide TFA has been shown to be active in reducing inflammation and increasing clearance of bacterial infections.Dusquetide TFA regulates innate immune respo... | |||
T60453 | TrxR-IN-3 | ||
TrxR-IN-3 (Compound 2c) is a effective TrxR inhibitor. TrxR-IN-3 shows strong antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and l... |