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ML162

Catalog No. T8970 CAS 1035072-16-2

ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)

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ML162, CAS 1035072-16-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)

Molecular Weight	477.4
Formula	C23H22Cl2N2O3S
CAS No.	1035072-16-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. WeiWer M , Bittker J A , Lewis T A , et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22(4):1822-1826.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Ferroptosis Compound Library Bioactive Compound Library

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Keywords

ML162 1035072-16-2 代谢凋亡细胞周期氧化还原 Ferroptosis Glutathione Peroxidase GPX p62 GPX4 ML-162 Nrf2 anticancer HRAS Inhibitor inhibit ML 162 inhibitor

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