p110β — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T28416	PIK-108	PIK 108,PIK108	PI3K
	PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).		PI3K
T2661	TGX-221	TGX221	PI3K
	TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.		PI3K
T6087	AZD 6482	KIN 193,AZD6482	DNA-PK , PI3K , Autophagy
	AZD 6482 (AZD6482) is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.		DNA-PK , PI3K , Autophagy
T1827	Buparlisib	BKM120,NVP-BKM120	Apoptosis , PI3K
	Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).		Apoptosis , PI3K
T6938	PF-4989216	PF 4989216	Apoptosis , PI3K
	PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.		Apoptosis , PI3K
T11381	Pictilisib dimethanesulfonate	GDC-0941 dimethanesulfonate,GDC-0941 2 MeSO3H salt	Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
	Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).		Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
T2083	PI-3065	PI3065	DNA-PK , PI3K , mTOR
	PI-3065 is a novel potent and selective PI3K p110δ inhibitor.		DNA-PK , PI3K , mTOR
T2667	PIK-75		Apoptosis , DNA-PK , PI3K
	PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).		Apoptosis , DNA-PK , PI3K
T2235	Dactolisib	BEZ235,NVP-BEZ235	ATM/ATR , PI3K , mTOR , Autophagy
	Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).		ATM/ATR , PI3K , mTOR , Autophagy
T24873	TGX-115	TGX 115	PI3K
	TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regulates platelet adhesion and inhibits phosphoinositide (PI) 3...		PI3K
T2287	PIK-75 hydrochloride	PIK-75 HCl,PIK-75	Apoptosis , DNA-PK , PI3K
	PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.		Apoptosis , DNA-PK , PI3K
T6143	PI-103	PI103,PI 103	Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
	PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).		Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
T3348	PIK-293	PIK293	PI3K
	PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.		PI3K
T1988	Duvelisib	INK1197,IPI-145	PI3K
	Duvelisib (INK1197) is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic a...		PI3K
T7014	Voxtalisib	XL765,SAR245409	DNA-PK , PI3K , mTOR
	Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.		DNA-PK , PI3K , mTOR
T16365	Buparlisib Hydrochloride	NVP-BKM120 Hydrochloride,BKM120 Hydrochloride	Others
	Buparlisib Hydrochloride is an inhibitor of pan-class I PI3K (IC50: 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively).		Others
T3153	Serabelisib	TAK-117,INK1117,MLN1117	PI3K , mTOR
	Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).		PI3K , mTOR
T12658	(Rac)-AZD 6482	(Rac)-KIN-193	Others
	(Rac)-AZD 6482 is the racemate of AZD 6482. AZD 6482 is a potent and selective inhibitor of p110β (IC50 of 0.69 nM).		Others
T81791	MIPS-21335		PI4K
	MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ with IC50 values of 0.043, 0.140, 0.386, and 0.742 μM, respective...		PI4K
T15592	IPI-3063		PI3K
	IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).		PI3K