lymph — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15598	Isosulfan blue		Others
	Isosulfan blue is a blue dye for the identification of lymph vessels during lymphangiography. Isosulfan blue is used during sentinel lymph node biopsies in breast cancer. However, Isosulfan blue may be a cause of allergi...		Others
T5S1550	Cinnamyl alcohol	Cinnamic Alcohol,Styryl Carbinol	PPAR
	Cinnamyl alcohol (Styryl Carbinol) readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.		PPAR
T76978	Siltuximab	CNTO-328	IL Receptor
	Siltuximab（CNTO-328） is a monoclonal antibody with anti-tumor activity targeting IL-6 for the study of giant lymph node hyperplasia (MCD) and COVID-19.		IL Receptor
T36454	1-Stearoyl-rac-glycerol
	1-Stearoyl-rac-glycerol is a monoacylglycerol that contains stearic acid at the sn-1 position. 1-Stearoyl-rac-glycerol levels are decreased in tumor tissue in a mouse model of azoxymethane-induced colorectal carcinogenes...
T27884	LY 183648	LY-183648,LY183648
	LY 183648 has antiestrogenic activity. LY117018 inhibited PAIII metastasis to the gluteal (97%) and iliac lymph nodes (88%).
T23898	Clocoumarol	Clocoumarolum,BRN 1264788,DB 112
	Clocoumarol is an anticoagulant that prevents blood clotting. It also can inhibit the dilatation of the spleen and the congestion of lymph nodes.
T35821	CAY10721
	CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph no...
T78458	IR 813 tosylate
	IR 813 tosylate is a near-infrared (NIR) fluorescent dye with excitation and emission wavelengths of 815 nm and 840 nm, respectively, utilized for visualizing regional lymph nodes in mice [1].
T41175	OB 24 hydrochloride
	OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in adv...
T75154	ATU027
	ATU027, a small interfering RNA (siRNA), silences protein kinase N3 (PKN3) expression in the vascular endothelium. It has been demonstrated to thwart local tumor invasion, as well as lymph node and pulmonary metastasis, ...
T79791	Immunosuppressant-1		Apoptosis
	Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects, including the induction of apoptosis in activated lymph node ce...		Apoptosis
T1120L2	Dacarbazine citrate	DTIC citrate
	Dacarbazine citrate is an alkylating agent used to treat cancers of the lymphatic system and malignant melanoma (a type of skin cancer) in patients with certain conditions: islet cell carcinoma (part of the pancreas) Sof...
T81400	Pritumumab
	Pritumumab, a natural human IgG1kappa monoclonal antibody (mAb), was first isolated from the regional draining lymph node of a cervical carcinoma patient. It specifically recognizes cell-surface-expressed vimentin on mal...
T60895	JAK-2/3-IN-3
	JAK-2-/3-IN-3 (compound ST4j) can be used in lymph derived diseases and leukemia research. JAK-2-/3-IN-3 inhibits JAK2 autophosphorylation and induces apoptosis in a time- and dose-dependent manner. JAK-2-/3-IN-3 is a po...
T37548	Azido-FTY720	azido-FTY720
	FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survi...
T78451	Patent Blue V	Acid blue 1
	Patent Blue V (Acid blue 1), a biological dye, serves as an intraocular stain in retinectomy—surgical removal of the inner limiting membrane (ILM). Its use facilitates the complete excision of premembrane structures in v...
T83910	S1PL-IN-31	Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
	S1PL-IN-31 is a dual-function chemical compound acting as an inhibitor of sphingosine-1-phosphate (S1P) lyase with an IC50 value of 210 nM and as an antagonist of the Smoothened (Smo) receptor with an IC50 of 440 nM. Dem...
T35829	CC-90005
	CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by I...