electrophilic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4385	PF-4840154		TRP/TRPV Channel
	PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.		TRP/TRPV Channel
T8483	Cysteine thiol probe	Methyl (4-bromobenzoyl)-L-cysteinate	Others
	Cysteine thiol probe (Methyl (4-bromobenzoyl)-L-cysteinate) is a chemoselective thiol probe for detection of electrophilic metabolites		Others
T7995	α-Angelica lactone	Alpha-Angelica Lactone	Others , GST
	α-Angelica lactone has cardiotonic activity, may exert their effects by providing an increased contraction-dependent calcium pool to be released upon systolic depolarization.		Others , GST
T9432	6-Bromo-2-naphthol		Others
	6-Bromo-2-naphthol is an electrophilic carbene intermediate.		Others
PDK0015	4-Hydroxycoumarin		Endogenous Metabolite , Antibacterial , AChR
	4-Hydroxycoumarin is a coumarin derivative and one of the versatile heterocyclic scaffolds with electrophilic and nucleophilic properties.		Endogenous Metabolite , Antibacterial , AChR
TN6750	2-tert-Butyl-1,4-benzoquinone		Nrf2
	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its negative regulator Keap1 in RAW264.7 cells.		Nrf2
T31413	DiaAlk
	DiaAlk is a clickable, electrophilic diazene probe which enables capture and site-centric proteomic analysis of oxidative post-translational modification (OxiPTM).
T73542	DB008
	DB008, a potent and selective PARP16 inhibitor, exhibits an IC50 value of 0.27 μM, incorporating an acrylamide electrophilic reagent. This membrane-permeable compound specifically targets PARP16.
T78949	AM841		Cannabinoid Receptor
	AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor. It diminishes forskolin-stimulated cAMP accumulation and slows gastroi...		Cannabinoid Receptor
T81776	MN551
	MN551 is a potent inhibitor that targets the cysteine-directed electrophilic covalent activity essential for the function of SOCS2 within its CRL5 complex. This compound also acts as an E3 ligase mediator, facilitating P...
T78158	MitoCur-1		Others
	MitoCur-1, a curcumin analogue, acts as an inhibitor of mitochondrial antioxidative enzyme thioredoxin reductase 2 (TrxR2), possessing electrophilic characteristics with mitochondrial-targeting capabilities. This compoun...		Others
TNU0658	2-bromomethyl benzothizaole
	2-bromomethyl benzothizaole is a derivative of benzothiazole. It is an intermediate and building block electrophilic reagent that has been used in the synthesis of many compounds such as 2-bromo-4-methyl-1,3-benzothiazol...
T36614	DL-Sulforaphane N-acetyl-L-cysteine
	Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressor...
T37452	Stephacidin B
	Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, includ...
T37594	Pericosine A
	Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lin...