colonic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0081	Lafutidine	FRG-8813	5-HT Receptor , Histamine Receptor
	Lafutidine (FRG-8813) is a newly developed histamine H(2)-receptor antagonist, which can inhibit gastric acid secretion.		5-HT Receptor , Histamine Receptor
T13385	Zamifenacin fumarate	UK-76654 fumarate	AChR
	Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.		AChR
T4S0554	Theaflavine-3,3'-digallate	TFBG,theaflavin digallate	Others
	1. Theaflavine-3,3'-digallate (theaflavin digallate) and lactic acid together could reduce herpes simplex virus transmission.		Others
T5254	Glycodeoxycholate Sodium	Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt	Others , Endogenous Metabolite
	Glycodeoxycholate Sodium (Glycodeoxycholic acid sodium salt) induces Apoptosis in hepatocytes by a mechanism associated with DNA cleavage by endonucleases. It is a secondary bile acid produced by the action of enzymes ex...		Others , Endogenous Metabolite
T5259	Glycochenodeoxycholic acid sodium salt	GCDCA,Sodium glycochenodeoxycholate	Apoptosis , Others , Endogenous Metabolite
	Glycochenodeoxycholic acid sodium salt (GCDCA) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environmen...		Apoptosis , Others , Endogenous Metabolite
T5234	Glycoursodeoxycholic acid	Ursodeoxycholylglycine,GUDCA	Others , Endogenous Metabolite
	Glycoursodeoxycholic acid (Ursodeoxycholylglycine) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic enviro...		Others , Endogenous Metabolite
T0918	Trimebutine	Mebutin	Opioid Receptor
	Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritabl...		Opioid Receptor
T36126	TMP-153
	Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and choleste...
T30640	Butyrylcholine	BA 51 090059,BA-51-090059,BA 51090059,BA 51-090059
	Butyrylcholine is a novel colonic ion transport regulator produced by colonic epithelial cells that stimulates nicotine and muscarinic receptors.
T34710	STA 2	ONO 11113,STA-2,STA2
	STA 2 is an analogue of TXA2, a thromboxane receptor in the colonic epithelium.
T29887	Aloe emodin anthrone
	Aloe emodin anthrone is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.
T33443	MK-8970
	MK-8970 is an acetal carbonate prodrug of raltegravir with enhanced colonic absorption.
T71738	DRAinh-A250
	DRAinh-A250 is a SLC26A3 inhibitor which blocks colonic fluid absorption and reduces constipation.
T17283	Zamifenacin	UK-76654	Others
	Zamifenacin obviously decreases colonic motility in irritable bowel syndrome. Zamifenacin is an effective gut-selective muscarinic M3 receptor antagonist.		Others
T29888	Aloe-emodin-glucoside
	Aloe-emodin-glucoside is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.
T35374L	(Ala13)-Apelin-13 acetate		Apelin receptor
	(Ala13)-Apelin-13 acetate, an APJ antagonist, modulates CRF-induced enhanced colonic motility, visceral sensation, and gut barrier.		Apelin receptor
T68735	Ciclotropium (free base)
	Ciclotropium (free base) is quaternary ammonium compound with anticholinergic and parasympatholytic activity. Oral Cyclotropium bromide inhibited fasting and meal-stimulated colonic motility significantly without causing...
T35708	N-acetyl-5-Aminosalicylic Acid
	N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-ac...
T76319	Urocortin III (mouse) (free acid)
	Urocortin III (mouse) (free acid), a selective agonist with high affinity for the CRF2 receptor, significantly inhibits gastric emptying while not affecting colonic transit [1] [2].
TN1834	Kobusin		Others , NOS , NF-κB
	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and ...		Others , NOS , NF-κB