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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15012 | Crolibulin | EPC2407 | Microtubule Associated |
Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization. | |||
T0320 | Colchicine | Colcin,Colchineos,Colchisol | Apoptosis , Microtubule Associated , Autophagy |
Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding to microtubule proteins. Colchicine can be used in the treatment of... | |||
T67935 | Tubulin inhibitor 11 | Apoptosis , Microtubule Associated | |
Tubulin Inhibitor 11 is a potent, orally active agent that inhibits tubulin by targeting the Colchicine binding site. It impedes tubulin polymerization, leading to mitotic blockade and apoptosis. | |||
T65128 | Tartaric acid disodium dihydrate | Disodium L-(+)-Tartrate Dihydrate | Phosphatase , Endogenous Metabolite |
Tartaric acid disodium dihydrate (Disodium L-(+)-Tartrate Dihydrate) is commonly used as a buffer in molecular biology and cell culture.Tartaric acid disodium dihydrate is an acid phosphatase inhibitor that increases the... | |||
T2511 | Plinabulin | NPI-2358 | Microtubule Associated |
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, the... | |||
T25290 | DAT1 | DAT-1,DAT 1 | |
DAT1 is an antimitotic and antiangiogenic that acts by binding to the colchicine binding site of tubulin. | |||
T28048 | Mivobulin Isethionate | NSC-613863,CI-980,NSC-635370,NSC-613862,NSC-350386 | |
Mivobulin is a tubulin inhibitor potentially for the treatment of glioma, malignant melanoma, prostate, ovarian cancer. CI-980 acts at the colchicine-binding site. | |||
T61084 | Tubulin polymerization-IN-37 | ||
Tubulin polymerization-IN-37 is a potent inhibitor (IC50: 2.3 μΜ) of tubulin polymerization by binding specifically to the colchicine site of tubulin and preventing colchicine binding. It has potential applications in ca... | |||
T71974 | ABI-274 | ||
ABI-274 is a novel potent colchicine binding site inhibitor (CBSI) and tubulin inhibitor. | |||
T68873 | Cornigerine | ||
Cornigerine is a natural product analog of colchicine produced by Colchicum cornigerum that inhibited tubulin polymerization both with and without microtubule-associated proteins, inhibited the binding of radiolabeled co... | |||
T60758 | Tubulin polymerization-IN-36 | ||
Tubulin polymerization-IN-36 is able to be used in cancer research, for example, lymphomas. Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding, that is an inhibitor of tu... | |||
T61728 | MY-875 | ||
MY-875 is a potent microtubulin polymerization inhibitor that competes at colchicine binding sites, exhibiting an IC50 value of 0.92 μM. It effectively suppresses microtubulin polymerization, exerting its inhibitory effe... | |||
T72167 | Tubulin polymerization-IN-39 | ||
Tubulin polymerization-IN-39, a tubulin polymerization inhibitor with an IC50 of 4.9 μM, targets the colchicine-binding site to hinder tubulin polymerization. This compound effectively suppresses cancer cell proliferatio... | |||
T40367 | Combretastatin A-1 phosphate tetrasodium | Combretastatin A-1 phosphate tetrasodium,OXi-4503 tetrasodium | |
Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a prodrug of Combretastatin A-1, is a tubulin-binding microtubule polymerization inhibitor that targets the colchicine-binding site. By inducing tubulin depolymerizati... | |||
T61880 | Tubulin polymerization-IN-26 | ||
Tubulin polymerization-IN-26 (compound 12h) is a chemical compound that inhibits the polymerization of microtubulin. It achieves this by binding to the colchicine binding site of microtubulin, with an IC50 value of 4.64 ... | |||
T69557 | ABI-231 HCl | ||
ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. ABI-231, has an average IC50 = 5.2 nM against pa... | |||
T71217 | MPT0B214 | ||
MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activ... | |||
T79341 | Tubulin polymerization-IN-45 | ||
Tubulin polymerization-IN-45, a tubulin-targeting agent, acts as a tubulin polymerization inhibitor by binding to the tubulin's colchicine site. It induces apoptotic cell death in hepatocellular cancer (HCC) cells [1]. | |||
T70906 | EHT-6706 | ||
EHT-6706 is a novel microtubule-disrupting agent that targets the colchicine-binding site to inhibit tubulin polymerization. At low nM concentrations, EHT 6706 exhibits highly potent antiproliferative activity on more th... | |||
T71116 | MPT0B098 | ||
MPT0B098 is a potent microtubule inhibitor through binding to the colchicine-binding site of tubulin. MPT0B098 is active against the growth of various human cancer cells, including chemoresistant cells with IC50 values r... |