bronchoconstriction — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T26519	Ablukast	Ro 23-3544	Leukotriene Receptor
	Ablukast (Ro 23-3544) is a leuktriene receptor antagonist. Ablukast acts as an anti-asthmatic.		Leukotriene Receptor
T6397	Atracurium besylate	Tracrium,51W89,BW-33A	AChR
	Atracurium besylate (51W89) is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for eliminat...		AChR
T1682	Methacholine Chloride	Mecholyl chloride,Acetyl-β-methylcholine chloride	AChR
	Methacholine Chloride (Acetyl-β-methylcholine chloride) is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower r...		AChR
T3148	MK-571 sodium	L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor , LTR
	MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ...		Leukotriene Receptor , LTR
T67957	Pipoxizine
	Pipoxizine has an antagonistic effect on histamine-induced bronchoconstriction and may be used in the study of asthma disease.
T68094	Lodoxamide ethyl		Others
	lodoxamide ethyl is a new orally active anti-allergic compound for the prevention of antigen-induced bronchoconstriction and blockage of skin allergic reactions.		Others
T68090	Laprafylline		Others
	Laprafylline is a xanthine compound with inhibitory effects on bronchoconstriction in vivo and antitumor activity.Laprafylline acts as a competitive serotonergic antagonist at low concentrations, and inhibits constrictio...		Others
T68173	ZD-2138	Ici-D2138	Lipoxygenase
	ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolat...		Lipoxygenase
T11388	Gemilukast	ONO-6950	Others
	Gemilukast (ONO-6950) is an orally active and potent dual inhibitor of cysteinyl leukotriene 1 and 2 receptors (CysLT1 and CysLT2), inhibits LTC 4-induced bronchoconstriction, and is inhibitory to human CysLT1 and CysLT2...		Others
T2520	Desloratadine	Sch34117,NSC 675447	Endogenous Metabolite , Histamine Receptor
	Desloratadine (Sch34117) is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smoot...		Endogenous Metabolite , Histamine Receptor
T1115	Doxylamine succinate	Decapryn	Histamine Receptor
	Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ...		Histamine Receptor
T71412	S 9795
	S 9795 is a methylxanthine derivative and acts as a potent inhibitor of bronchoconstriction in vivo.
T71541	ASP9133
	ASP9133 is a long-acting muscarinic antagonist (LAMA) which shows more selective inhibition of bronchoconstriction against salivation and more rapid onset of action than tiotropium bromide.
T26811	BI-L 239	BIL239,Enofelast,BI-L-239
	BI-L 239 is an inhibition of 5-lipoxygenase products that cause bronchoconstriction.
T68723	FPL-59257
	FPL-59257 is a leukotriene antagonist that has been shown to abolish cough response & partly inhibit bronchoconstriction produced by leukotrienes C & D.
TP1999	MEN 11270
	Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3); conformationally constrained cyclized analog of HOE 140. Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other recept...
T21951	CDP 840 hydrochloride
	CDP-840 (GR259653X) is a potent, selective and orally active phosphodiesterase IV (PDE IV) inhibitor, which selectively inhibits antigen-induced early and late phase bronchoconstriction in conscious squirrel monkeys [1].
T28015	Mequitamium iodide	LG-30435,LG 30435,LG30435
	Mequitamium iodide is a platelet activating factor (PAF) inhibitor. Mequitamium inhibits PAF-acether induced platelet aggregation and bronchoconstriction. Mequitamium is capable of inhibiting platelet-mediated effects of...
T36214	16,16-dimethyl Prostaglandin E1	16,16-dimethyl Prostaglandin E1
	16,16-dimethyl Prostaglandin E1 is a PGE1 (T1626) analog that induces bronchoconstriction and vascular smooth muscle contraction and inhibits indomethacin-induced cell elongation.
T38157	Ricinelaidic Acid
	Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). It inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neu...