biotransformation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T41044	Naringinase		Glucosidase
	Naringinase is a hydrolytic enzymatic complex that exhibits α-L-rhamnosidase and β-D-glucosidase activities. It is widely found in nature and is primarily utilized for the biotransformation of steroids, antibiotics, and ...		Glucosidase
T3881	Vaccarin		Integrin , Akt , PERK , AMPK
	Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation.		Integrin , Akt , PERK , AMPK
Fr13756	Isonicotinic acid		Endogenous Metabolite , Drug Metabolite
	Isonicotinic acid is a metabolite of Isoniazid.Isonicotinic acid is a useful isomer of nicotinic acid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the biotransformation also to be catalyzed by cyt...		Endogenous Metabolite , Drug Metabolite
T6S1559	Aurantio-obtusin		Others
	1. Biotransformation of glucoAurantio-obtusin towards Aurantio-obtusin increased the toxicity of irinotecan through increased inhibition of SN-38 glucuronidation. 2. Aurantio-obtusin, stimulated chemotactic migration of ...		Others
T16279	Nebicapone	BIA 3-202	Others
	Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to ...		Others
T76114	Diaphorase
	Diaphorase, derived from anaerobic sludge organisms, catalyzes the denitrification biotransformation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) [1].
T83584	(±)-Lavandulol
	(±)-Lavandulol, an atypical monoterpene alcohol, undergoes biotransformation by the fungal strain Rhizopus oryzae to yield its oxygenated metabolite [1].
T83241	7-Hydroxy-TSU-68
	7-Hydroxy-TSU-68 is a derivative and metabolite of TSU-68, originating from the self-induced hydroxylation of TSU-68 in human liver microsomes, indicative of its biotransformation pathway [1].
T83320	4'-Demethylpodophyllotoxone
	4'-Demethylpodophyllotoxone, an intermediate in the biotransformation pathway of Alternaria alternata S-f6, undergoes further modification with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP). This modification yields a novel ...
T35431	(±)-Clopidogrel (hydrochloride)
	Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex ...
T36112	Clopidogrel Carboxylic Acid (hydrochloride)
	Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex ...
T83786	8-Chloroadenosine-5'-triphosphate sodium	8-chloro ATP
	8-Chloroadenosine-5’-triphosphate (8-chloro ATP), a potent metabolite of the anticancer agent 8-chloro cyclic AMP (cAMP) and a nucleotide derivative, is produced through the biotransformation of 8-chloro cAMP into 8-chlo...
T13421	(-)-Cevimeline hydrochloride hemihydrate	(-)-SNI-2011,(-)-AF102B hydrochloride hemihydrate	ALK
	Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is being explored as a potential treatment for xerostomia in Sjogren's syndrome, exhibiting an IC50 value indicative of its affini...		ALK
T35635	Rac-trans-4-hydroxy Glyburide
	rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide .1,2It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9.1rac-trans-4-hydroxy Glybu...