autotaxin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10415	Autotaxin-IN-3		PDE
	Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.		PDE
T22086	HA 155	Autotaxin Inhibitor IV	PDE
	HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.		PDE
T10418	Autotaxin modulator 1		PDE
	Autotaxin modulator 1 is a new modulator of Autotaxin.		PDE
T10416	Autotaxin-IN-4		PDE
	Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.		PDE
T10417	Autotaxin-IN-5		PDE
	Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.		PDE
T14352	Autotaxin-IN-1		PDE
	Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1].		PDE
T72837	Autotaxin-IN-6
	Autotaxin-IN-6 (compound 23) is a potent inhibitor of autotaxin (ATX), exhibiting an IC50 of 30 nM, and is capable of attenuating cell migration with potential applications in anticancer research [1].
T11533	Z-HA155	CS-963	PDE
	Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.		PDE
T10545	BIO-32546		PDE
	BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.		PDE
T2646	HA130		PDE
	HA130 is a selective ATX (autotaxin) inhibitor.		PDE
T31101	CRT0273750	CRT 0273750,CRT-0273750	PDE
	CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.		PDE
T63190	Cudetaxestat	BLD-0409	PDE
	Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.		PDE
T4041	Ziritaxestat	GLPG1690	PDE
	Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.		PDE
T3631	PF-8380		PDE
	PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhib...		PDE
T38759	ONO-8430506		PDE
	ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.		PDE
T10409	ATX inhibitor 5		PDE
	ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50 : 15.3 nM) that reduces the level of CCl4-induced hepatic fibrosis and has anti-hepatic fibrosis effects,.		PDE
T12372	PAT-505		EGFR
	PAT-505 is an orally available, selective and potent inhibitor of autologous epidermal growth factor (IC50 2 nM in Hep3B cells, 9.7 nM in human blood, 62 nM in mouse plasma).		EGFR
T23293	S32826 disodium	S 32826	Others
	autotaxin inhibitor		Others
T28299	PAT-078	PAT078,PAT 078
	PAT-078 is an inhibitor of type II autotaxin.
T28301	PAT-494	PAT 494,PAT494
	PAT-494 is an inhibitor of type II Autotaxin.