antitumor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10341	Antitumor agent-19		Others
	Antitumor agent-19 is a modulator of tumor-associated macrophages with EC50s of 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells.		Others
T10342	Antitumor agent-2		Others
	Antitumor agent-2 has anti-inflammatory and anti-tumor activity and can be used to study cancer.		Others
T3389	Antitumor agent-21	TRX818	Others
	Antitumor agent-21 (TRX818) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities.		Others
T39889	Antitumor agent-23
	Antitumor agent-23 exhibits potent antitumoral activity, as demonstrated by its GI50 values of 38, 48, 5, 27, 80, and 28 nM against the lymphoma cell lines GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI respe...
T39523	Antitumor agent-28
	Antitumor agent-28 is a compound that specifically targets and inhibits the activity of the ataxia telangiectasia mutated (ATM) kinase. By doing so, it effectively impedes the progression of ATM-mediated diseases and dem...
T14296	Antitumor agent-3		Others
	Antitumor agent-3 is a potent compound. It comprises a new imidazopyridine having excellent antitumor activity as an active ingredient.		Others
T12443	Antitumor agent-4		Others
	Antitumor agent-4 is a butenylphenyl phosphate derivative, is an agent of mammary cancer and anovulatory sterility.		Others
T63513	Antitumor agent-71
	Antitumor Agent-71 is an antitumor compound that exhibits an inhibitory effect on tubulin aggregation. antitumor Agent-71 possesses an anti-proliferative effect with IC50 values ranging from 3.98-15.70 μM against tumor c...
T72523	Antitumor agent-46
	Antitumor agent-46 is an anti-tumor agent. Antitumor agent-46 demonstrates markedly higher antiproliferative activity on MCF-7 cells with an IC 50 value of 2.08 µM .
T62480	Antitumor agent-51
	Antitumor agent-51 is effective and selective in inhibiting the growth and migration of osteosarcoma cells, acting on MNNG/HOS cells (IC50: 21.9 nM). antitumor agent-51 is less toxic and extremely bioavailable.
T83011	Antitumor agent-105
	Antitumor Agent-105 (Compound 37) exhibits antitumor activity, demonstrating inhibition of A549, H1299, H460, HCT116, and MDA-MB-231 cells with respective IC50 values of 6.7, 8.3, 4.3, 4.4, and 6.7 μM [1].
T79466	Antitumor agent-111		c-Met/HGFR
	Antitumor Agent-111 (Compound 46), a c-Met kinase inhibitor (IC50 = 46 nM), exhibits both antitumor and antiproliferative effects. It impedes the cell cycle at the G0/G1 phase and induces apoptosis [1].		c-Met/HGFR
T64111	Antitumor agent-76
	Antitumor agent-76 is a water-soluble, orally active, rapid-release prodrug of Triptolide that exhibits anticancer effects.
T83000	Antitumor agent-89
	Antitumor agent-89 (Compd OTS-5), a naturally occurring compound, exhibits weak inhibitory activity against fMLP-induced superoxide generation [1].
T64128	Antitumor agent-56
	Antitumor agent-56 is an orally active triptolide derivative that significantly inhibits melanoma growth, exhibiting anti-tumour, anti-inflammatory and NO-releasing effects.
T79463	Antitumor agent-110		Apoptosis
	Antitumor Agent-110 (Compound 13), an imidazotetrazine anticancer agent, exhibits excellent permeability. It halts the cell cycle at the G2/M phase and induces apoptosis [1].		Apoptosis
T74601	Antitumor photosensitizer-3
	Antitumor Photosensitizer-3 (Compound I), a chlorin derivative, effectively induces apoptosis and necrosis in tumor cells upon exposure to 650 nm laser irradiation. This compound demonstrates reduced skin phototoxicity c...
T79582	Antitumor agent-116		MELK
	Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis. It demonstrates binding affinity for the MELK receptor [1].		MELK
T79265	Antitumor agent-104		PARP
	Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme activity and reduction of PAR protein levels. Additionally, ...		PARP
T74950	Antitumor agent-73		STAT
	Antitumor Agent-73, a derivative of Diosgenin, both impedes STAT3 signaling and exogenously stimulates Pdia3/ERp57. This compound demonstrates significant antineoplastic efficacy, exhibiting potency against diverse cance...		STAT