alopecia — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21936	M50054		Caspase
	Apoptosis Inhibitor was a novel inhibitor of programmed cell death associate with caspase-3 inhibition.		Caspase
T0488	Finasteride	MK-906	Reductase
	Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.		Reductase
T21444	Diphenylcyclopropenone	DPCP,Diphencyprone	Others
	Diphenylcyclopropenone (DPCP) is a topical drug used to treat alopecia areata, alopecia totalis, and refractory warts. Diphencyprone acts as a local stimulator that triggers an immune response against the action of autor...		Others
T10889	CRTh2 antagonist 2		GPR
	CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia.		GPR
T3378	Alpha-Estradiol	Alfatradiol,17α-Estradiol,Epiestrol,Epiestradiol	Estrogen/progestogen Receptor , Reductase , Endogenous Metabolite
	Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.
T27798	Lapisteride	CS891B,CS-891,CS-891B,CS891	Others
	Lapisteride (CS-891) a steroidal 5α-reductase inhibitor is used to treat benign prostatic hyperplasia (BPH) and androgenetic alopecia and may be effective in preventing or treating AGA .		Others
T17256	Wnt pathway activator 1		Wnt/beta-catenin
	Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM. Wnt pathway activator 1 is a potent Wnt activator for the treatment of androgenetic alopecia (AGA).		Wnt/beta-catenin
T10636	5α-reductase-IN-1		Others
	5α-reductase-IN-1 is a potent inhibitor of the enzyme 5α-reductase. This compound is primarily employed in research studies to investigate its potential efficacy in treating patterned alopecia. It is commonly used in com...		Others
T28358	PF 00277343	PF-00277343,PF00277343
	PF 00277343, a thyroid receptor agonist, is used for the treatment of androgenetic alopecia.
T82202	H-Gly-Leu-Phe-OH
	GLF (H-Gly-Leu-Phe-OH), a tripeptide isolated from α-lactalbumin with immunostimulatory properties, prevents alopecia, epidermal thickening, and adipocyte layer thinning induced by the anticancer agent Etoposide [1].
T38467	(Rac)-PF-998425
	(Rac)-PF-998425 is a potent, selective, nonsteroidal antagonist of the androgen receptor (AR), with IC50 values of 26 nM and 90 nM in AR binding and cellular assays, respectively. This compound shows promise for investig...
T27519	GW 9578	GW9578,GW-9578	PPAR
	GW 9578 is a selective and potent PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.		PPAR
T61029	TP0427736 hydrochloride
	TP0427736 hydrochloride can be used in the androgenic alopecia (AGA) research. TP0427736 hydrochloride inhibits the phosphorylation of Smad2/3 in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydr...
T21668	Finasteride acetate
	Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC 50 of 4.2 nM for type II 5α-reductase. The affinity of Finasteride acetate for type II 5α-reductase enzyme was approximately 100...