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Finasteride

Catalog No. T0488 CAS 98319-26-7

Synonyms: MK-906

Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.

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Finasteride, CAS 98319-26-7

Pack Size	Availability	Price/USD
50 mg	In stock	$ 35.00
100 mg	In stock	$ 48.00
200 mg	In stock	$ 80.00
500 mg	In stock	$ 128.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.49%

Purity: 99.04%

Purity: 98.4%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.
Targets&IC50	5α reductase:10. nM(Ki)
In vitro	After 4, 9, 14, and 21 days, rat prostates were excised to measure androgen and DNA content and to undergo histological and morphological analyses. On day 21, finasteride levels decreased by 65%. Finasteride treatment induced a dose-dependent increase in the incidence of hypospadias (penischisis) in male offspring, with a threshold dose level of approximately 0.1 mg/kg/day and a 100% effect level at 100 mg/kg/day (administered on gestational day 20). Additionally, finasteride reduced the anogenital distance in male offspring rats. After 4 days of treatment with finasteride, DNA content was almost unaffected, but a decrease of up to 52% was observed at 14 days. After prostate sections were stained, 23% of epithelial cells displayed markers of apoptotic cell death on day 14, returning to control levels by day 21. Finasteride caused 16% of epithelial cells to stain for tissue transglutaminase on day 9, with a return to baseline by day 14. Finasteride-induced staining was less intense at 4 days, peaking at 0.7% of epithelial cells and returning to control values by day 9.
In vivo	Finasteride inhibits the growth rate of prostate lymph node carcinoma cell lines in a dose-dependent manner and significantly suppresses the secretion and expression of prostate-specific antigen in LNCaP cells. It forms a ternary complex with the reduced coenzyme II of type 2 isoenzyme (Ki: 1.19 nM), which then rearranges into a high-affinity complex (E:Ⅰ) with an approximate first-order rate constant of 1.62ms.

Synonyms	MK-906
Molecular Weight	372.54
Formula	C23H36N2O2
CAS No.	98319-26-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 37.3 mg/mL (100 mM)

DMSO: 37.3 mg/mL (100 mM)

References and Literature

1. Azzolina B, et al. J Steroid Biochem Mol Biol, 1997, 61(1-2), 55-64. 2. Bologna M, et al. Urology, 1995, 45(2), 282-290. 3. Wang LG, et al. Cancer Res, 1997, 57(4), 714-719. 4. Clark RL, et al. Teratology, 1990, 42(1), 91-100. 5. Rittmaster RS, et al. Endocrinology, 1995, 136(2), 741-748.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Anti-Metabolism Disease Compound Library Metabolism Compound Library Orally Active Compound Library Human Metabolite Library NO PAINS Compound Library FDA-Approved Drug Library ReFRAME Related Library Endocrinology-Hormone Compound Library

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Keywords

Finasteride 98319-26-7 Endocrinology/Hormones Metabolism Reductase MK906 MK 906 androgenic prostatic 5α-reductase alopecia BPH benign inhibit hyperplasia Inhibitor 5 alpha Reductase type MK-906 inhibitor

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